PMID- 24123470 OWN - NLM STAT- MEDLINE DCOM- 20141118 LR - 20140320 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 39 IP - 4 DP - 2014 Apr TI - T1 mapping in the rat myocardium at 7 tesla using a modified CINE inversion recovery sequence. PG - 901-10 LID - 10.1002/jmri.24251 [doi] AB - PURPOSE: To evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE-IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla. MATERIALS AND METHODS: The recently published mCINE-IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations were used to study signal evolution and heart rate dependency. Gadolinium phantoms, a heart specimen and a healthy rat were used to study reproducibility. Two cryo-infarcted rats were scanned to measure late gadolinium enhancement (LGE). RESULTS: In the phantom reproducibility studies the T1 measurements had a maximum coefficient of variation (COV) of 1.3%. For the in vivo reproducibility the COV was below 5% in the anterior cardiac segments. In simulations with phantoms and specimens, a heart rate dependency of approximately 0.5 ms/bpm was present. The T1 maps of the cryo-infarcted rats showed a clear lowering of T1 in de LGE region. CONCLUSION: The results show that mCINE-IR is highly reproducible and that the sensitivity allows detecting T1 changes in the rat myocardium. CI - Copyright (c) 2013 Wiley Periodicals, Inc. FAU - Smit, Henk AU - Smit H AD - Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands. FAU - Guridi, Ruben Pellicer AU - Guridi RP FAU - Guenoun, Jamal AU - Guenoun J FAU - Poot, Dirk H J AU - Poot DH FAU - Doeswijk, Gabriela N AU - Doeswijk GN FAU - Milanesi, Matteo AU - Milanesi M FAU - Bernsen, Monique R AU - Bernsen MR FAU - Krestin, Gabriel P AU - Krestin GP FAU - Klein, Stefan AU - Klein S FAU - Kotek, Gyula AU - Kotek G LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131007 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 SB - IM MH - *Algorithms MH - Animals MH - Image Enhancement/*methods MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Myocardial Infarction/*pathology MH - Myocardium/*pathology MH - Rats MH - Reproducibility of Results MH - Sensitivity and Specificity OTO - NOTNLM OT - CINE inversion recovery OT - T1 estimation OT - delayed enhancement OT - rat cardiac T1 EDAT- 2013/10/15 06:00 MHDA- 2014/11/19 06:00 CRDT- 2013/10/15 06:00 PHST- 2012/12/11 00:00 [received] PHST- 2013/05/09 00:00 [accepted] PHST- 2013/10/15 06:00 [entrez] PHST- 2013/10/15 06:00 [pubmed] PHST- 2014/11/19 06:00 [medline] AID - 10.1002/jmri.24251 [doi] PST - ppublish SO - J Magn Reson Imaging. 2014 Apr;39(4):901-10. doi: 10.1002/jmri.24251. Epub 2013 Oct 7.