PMID- 24124578
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 10
DP  - 2013
TI  - Association between tumor necrosis factor-alpha 308G/A gene polymorphism and 
      silicosis susceptibility: a meta-analysis.
PG  - e76614
LID - 10.1371/journal.pone.0076614 [doi]
LID - e76614
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) 308 G/A gene polymorphism has been 
      reported to be associated with susceptibility to silicosis. However, the relevant 
      study results are still inconsistent. OBJECTIVE AND METHODS: A meta-analysis was 
      performed in order to drive a more precise estimation of the relationship between 
      TNF-alpha-308 G/A gene polymorphism and susceptibility to silicosis. Electronic 
      databases were searched and nine separate studies were included. The pooled odds 
      ratios (ORs) and the corresponding 95% confidence internal (CI) were calculated 
      by a fixed effect model. RESULTS: A total of 1267 cases and 1214 controls were 
      included. In the overall analysis, significantly increased silicosis risk was 
      found (for GA+AA vs. GG OR=1.45, 95%CI: 1.20-1.760, P=1.58E4; for GA vs. GG: 
      OR=1.53, 95%CI=1.25-1.86, P=3.11E5; for A allele vs. G allele: OR=1.27, 
      95%CI=1.08-1.50, P= 0.004). In the subgroup analysis, significantly increased 
      silicosis risk was also found among Asians (for GA+AA vs. GG: OR=1.63, 
      95%CI=1.27-2.08, P=1.01E4), for GA vs. GG: OR=1.71, 95%CI=1.33-2.20, P=3.44E5), 
      for A allele vs. G allele: OR=1.45, 95%CI=1.17-1.80, P=0.001). However, no 
      significantly increased risk was found among non-Asians for all genetic models. 
      CONCLUSIONS: TNF-alpha-308 G/A polymorphism might lead to an increased risk of 
      silicosis susceptibility, especially for Asians. However, further studies with 
      large sample sizes should be conducted to confirm the association.
FAU - Li, Zhanzhan
AU  - Li Z
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Central South University, Changsha, Hunan Province, China.
FAU - Xue, Jing
AU  - Xue J
FAU - Yan, Shipeng
AU  - Yan S
FAU - Chen, Peng
AU  - Chen P
FAU - Chen, Lizhang
AU  - Chen L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20131004
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Codon)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Codon
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Silicosis/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3790741
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/10/15 06:00
MHDA- 2014/05/23 06:00
PMCR- 2013/10/04
CRDT- 2013/10/15 06:00
PHST- 2013/05/10 00:00 [received]
PHST- 2013/08/25 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
PHST- 2013/10/04 00:00 [pmc-release]
AID - PONE-D-13-19166 [pii]
AID - 10.1371/journal.pone.0076614 [doi]
PST - epublish
SO  - PLoS One. 2013 Oct 4;8(10):e76614. doi: 10.1371/journal.pone.0076614. eCollection 
      2013.