PMID- 24124671
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20141120
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 93
IP  - 22
DP  - 2013 Jun 11
TI  - [Clinical observation of cardiopulmonary exercise test in patients with 
      idiopathic pulmonary arterial hypertension].
PG  - 1683-6
AB  - OBJECTIVE: To explore the exercise characteristics of patients with idiopathic 
      pulmonary arterial hypertension (IPAH). METHODS: From November 2010 to September 
      2012 , 76 consecutive IPAH patients and 24 healthy controls from Fuwai 
      Cardiovascular Hospital were enrolled to undergo cardiopulmonary exercise 
      testing. The exercise parameters were compared. Correlations among peak oxygen 
      consumption, anaerobic threshold, peak oxygen pulse, New York Heart Association 
      (NYHA) class, N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-minute 
      walking distance (6 MWD) and cardiac index are analyzed in IPAH. RESULTS: There 
      were 21 males and 55 females in IPAH and 8 males and 16 females in controls. 
      Their mean ages were (31.5 +/- 10.6) and (35.5 +/- 6.4) years respectively. 
      Significant differences (P = 0.000) existed between two groups in peak oxygen 
      consumption ((12.7 +/- 3.3) vs (25.6 +/- 5.8) ml.min(-1).kg(-1)), anaerobic threshold 
      ((9.8 +/- 2.5) vs (16.7 +/- 3.9) ml.min(-1).kg(-1)), peak oxygen pulse ((5.3 +/- 1.6) 
      vs (9.9 +/- 2.5) ml/bpm) and ventilator efficiency (slope of minute ventilation in 
      relation to CO2 produced) ((42.6 +/- 2.0) vs (25.5 +/- 3.5)). In IPAH, peak oxygen 
      consumption was significantly correlated with NYHA class (r = -0.509, P = 0.000), 
      6 MWD (r = 0.443, P = 0.002) and NT-proBNP levels (r = -0.423, P = 0.011). And 
      anaerobic threshold was significantly correlated with NYHA class (r = -0.362, P = 
      0.002), 6MWD (r = 0.343, P = 0.004) and NT-proBNP levels (r = -0.275, P = 0.017). 
      Peak oxygen pulse and ventilator efficiency were both correlated well with total 
      pulmonary vascular resistance. Partial correlation analysis demonstrated that 
      there were significant correlations among peak oxygen consumption, anaerobic 
      threshold, NYHA class, NT-proBNP levels and 6MWD after adjusting for age, gender 
      and weight. CONCLUSIONS: Peak oxygen consumption and anaerobic threshold decrease 
      ventilator efficiency in IPAH patients. Cardiopulmonary exercise testing is an 
      invasive tool of assessing safely the function of IPAH patients.
FAU - Luo, Qin
AU  - Luo Q
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China.
FAU - Liu, Zhi-hong
AU  - Liu ZH
FAU - Ma, Xiu-ping
AU  - Ma XP
FAU - Zhao, Zhi-hui
AU  - Zhao ZH
FAU - Gu, Qing
AU  - Gu Q
FAU - Xiong, Chang-ming
AU  - Xiong CM
FAU - Ni, Xin-hai
AU  - Ni XH
FAU - He, Jian-guo
AU  - He JG
FAU - Zhao, Qing
AU  - Zhao Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Exercise Test
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*metabolism/*physiopathology
MH  - Male
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Oxygen Consumption
MH  - Young Adult
EDAT- 2013/10/16 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/10/16 06:00
PHST- 2013/10/16 06:00 [entrez]
PHST- 2013/10/16 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2013 Jun 11;93(22):1683-6.