PMID- 24125781
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20220410
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 112
DP  - 2013 Nov
TI  - Antidepressant-like activity of resveratrol treatment in the forced swim test and 
      tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation 
      of ERK.
PG  - 104-10
LID - S0091-3057(13)00241-4 [pii]
LID - 10.1016/j.pbb.2013.10.007 [doi]
AB  - Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has 
      diverse biological activities. There is only limited information about the 
      antidepressant-like effect of resveratrol. The present study assessed whether 
      resveratrol treatment (20, 40 and 80mg/kg, i.p., 21days) has an 
      antidepressant-like effect on the forced swim test (FST) and tail suspension test 
      (TST) in mice and examined what its molecular targets might be. The results 
      showed that resveratrol administration produced antidepressant-like effects in 
      mice, evidenced by the reduced immobility time in the FST and TST, while it had 
      no effect on the locomotor activity in the open field test. Resveratrol treatment 
      significantly reduced serum corticosterone levels, which had been elevated by the 
      FST and TST. Moreover, resveratrol increased brain-derived neurotrophic factor 
      (BDNF) protein and extracellular signal-regulated kinase (ERK) phosphorylation 
      levels in the prefrontal cortex and hippocampus. All of these antidepressant-like 
      effects of resveratrol were essentially similar to those observed with the 
      clinical antidepressant, fluoxetine. These results suggest that the 
      antidepressant-like effects of resveratrol in the FST and TST are mediated, at 
      least in part, by modulating hypothalamic-pituitary-adrenal axis, BDNF and ERK 
      phosphorylation expression in the brain region of mice.
CI  - (c) 2013.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Institute of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi 
      Road, Jinan, Shandong 250012, PR China.
FAU - Gu, Jianhua
AU  - Gu J
FAU - Wang, Xueer
AU  - Wang X
FAU - Xie, Kai
AU  - Xie K
FAU - Luan, Qinsong
AU  - Luan Q
FAU - Wan, Nianqing
AU  - Wan N
FAU - Zhang, Qun
AU  - Zhang Q
FAU - Jiang, Hong
AU  - Jiang H
FAU - Liu, Dexiang
AU  - Liu D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131011
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Stilbenes)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Hindlimb Suspension
MH  - *Hypothalamo-Hypophyseal System
MH  - Male
MH  - Mice
MH  - Phosphorylation
MH  - *Pituitary-Adrenal System
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - *Stress, Physiological
MH  - Swimming
OTO - NOTNLM
OT  - BDNF
OT  - Brain derived neurotrophic factor (BDNF)
OT  - ERK
OT  - Extracellular signal-regulated kinase (ERK)
OT  - FST
OT  - Forced swim test
OT  - HPA
OT  - PFC
OT  - RT-PCR
OT  - Resveratrol
OT  - TST
OT  - Tail suspension test
OT  - The hypothalamic-pituitary-adrenal axis
OT  - brain derived neurotrophic factor
OT  - extracellular signal-regulated kinase
OT  - forced swim test
OT  - hypothalamic-pituitary-adrenal
OT  - prefrontal cortex
OT  - reverse transcription-polymerase chain reaction
OT  - tail suspension test
EDAT- 2013/10/16 06:00
MHDA- 2014/07/17 06:00
CRDT- 2013/10/16 06:00
PHST- 2013/06/28 00:00 [received]
PHST- 2013/09/05 00:00 [revised]
PHST- 2013/10/05 00:00 [accepted]
PHST- 2013/10/16 06:00 [entrez]
PHST- 2013/10/16 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - S0091-3057(13)00241-4 [pii]
AID - 10.1016/j.pbb.2013.10.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2013 Nov;112:104-10. doi: 10.1016/j.pbb.2013.10.007. 
      Epub 2013 Oct 11.