PMID- 24127005
OWN - NLM
STAT- MEDLINE
DCOM- 20140528
LR  - 20131024
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 8
IP  - 6
DP  - 2013 Dec
TI  - Brain-derived neurotrophic factor expression in dorsal root ganglia of a lumbar 
      spinal stenosis model in rats.
PG  - 1836-44
LID - 10.3892/mmr.2013.1723 [doi]
AB  - This study aimed to investigate the expression of brain-derived neurotrophic 
      factor (BDNF) in dorsal root ganglia (DRG) of a rat model of lumbar spinal 
      stenosis (LSS). Adult male rats were divided into the operation and sham 
      operation groups. The operation group was comprised of the rat models of LSS. 
      Walking distance and BDNF expression levels in DRG were measured in the two 
      groups at different time points. The total BDNF protein levels and positive cell 
      mean optical density (MOD) values in the operation group were significantly 
      higher at each time point compared with that of the sham operation and 
      preoperative control groups (P<0.05). The total BDNF protein levels and MOD 
      values following sport in the operation group were significantly higher compared 
      with those prior to sport (P<0.05). In the sham operation group, BDNF protein 
      levels and MOD values before and after sport at each time point showed no 
      significant differences than those of the operation group (P>0.05). Moreover, 
      BDNF protein levels and MOD values in the operation group indicated a negative 
      correlation with walking distance. The present study demonstrated that the 
      expression of BDNF in rat models of LSS increased with time and was associated 
      with a decrease in walking distance. BDNF was therefore important for the process 
      of intermittent claudication caused by LSS.
FAU - Li, Qinliang
AU  - Li Q
AD  - Department of Spine, The Affiliated Lianyungang Hospital of Xuzhou Medical 
      College, Lianyungang, Jiangsu 222000, P.R. China.
FAU - Liu, Yi
AU  - Liu Y
FAU - Chu, Zhaoming
AU  - Chu Z
FAU - Chen, Jinchuan
AU  - Chen J
FAU - Dai, Fenglei
AU  - Dai F
FAU - Zhu, Xiaorong
AU  - Zhu X
FAU - Hu, Ankang
AU  - Hu A
FAU - Yun, Cai
AU  - Yun C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131011
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ganglia, Spinal/*metabolism/pathology/physiopathology
MH  - Immunohistochemistry
MH  - Lumbar Vertebrae/*metabolism/pathology/physiopathology
MH  - Male
MH  - Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Stenosis/*metabolism/pathology/physiopathology
MH  - Walking
EDAT- 2013/10/16 06:00
MHDA- 2014/05/29 06:00
CRDT- 2013/10/16 06:00
PHST- 2013/04/03 00:00 [received]
PHST- 2013/09/26 00:00 [accepted]
PHST- 2013/10/16 06:00 [entrez]
PHST- 2013/10/16 06:00 [pubmed]
PHST- 2014/05/29 06:00 [medline]
AID - 10.3892/mmr.2013.1723 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Dec;8(6):1836-44. doi: 10.3892/mmr.2013.1723. Epub 2013 Oct 11.