PMID- 24128085
OWN - NLM
STAT- MEDLINE
DCOM- 20140710
LR  - 20131122
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 29
IP  - 46
DP  - 2013 Nov 19
TI  - Self-assembly of peptide-amphiphile forming helical nanofibers and in situ 
      template synthesis of uniform mesoporous single wall silica nanotubes.
PG  - 14274-83
LID - 10.1021/la4024986 [doi]
AB  - A lysine based peptide amphiphile (PA) is designed and synthesized for efficient 
      water immobilization. The PA with a minimum gelation concentration (MGC) of 1% 
      w/v in water shows prolonged stability and can also efficiently immobilize 
      aqueous mixtures of some other organic solvents. The presence of a free amine 
      induced pH dependency of the gelation as the PA could form hydrogel at a pH range 
      of 1-8 but failed to do so above that pH. Various spectroscopic and microscopic 
      experiments such as steady state fluorescence, NMR, IR, CD, and FESEM reveal the 
      presence of hydrophobic interaction, hydrogen bond, and pi-pi stacking interaction 
      in the self-assembly process. The self-aggregation has been correlated with the 
      design of the molecule to show the involvement of supramolecular forces and the 
      hierarchical pathway. While the L analogue formed left-handed helical nanofibers, 
      the other enantiomer showed opposite helicity. Interestingly the equimolar 
      mixture of the isomers failed to form any fibrous aggregate. Although fibers 
      formed at a subgel concentration, no helical nature was observed at this stage. 
      The length and thickness of the fibers increased with increase in the gelator 
      concentration. The nanofibers formed by the gelator are used as a template to 
      prepare mesoporous single wall silica nanotubes (SWSNTs) in situ in plain water 
      without the requirement of any organic solvent as well as any external 
      hydrolyzing agent. The SWSNTs formed are open at both ends, are few micrometers 
      in length, and have an average diameter of ~10 nm. The BET isotherm showed a type 
      IV hysteresis loop suggesting mesoporous nature of the nanotubes.
FAU - Ahmed, Sahnawaz
AU  - Ahmed S
AD  - Department of Chemistry, Indian Institute of Technology Guwahati , North 
      Guwahati, Kamrup, Assam 781039, India.
FAU - Mondal, Julfikar Hassan
AU  - Mondal JH
FAU - Behera, Nibedita
AU  - Behera N
FAU - Das, Debapratim
AU  - Das D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131105
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Hydrogels)
RN  - 0 (Peptides)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Hydrogels/chemistry
MH  - Hydrogen Bonding
MH  - Hydrogen-Ion Concentration
MH  - *Hydrophobic and Hydrophilic Interactions
MH  - Lysine/chemistry
MH  - Models, Molecular
MH  - Nanofibers/*chemistry
MH  - Nanotubes/*chemistry
MH  - Peptides/*chemistry
MH  - Protein Structure, Secondary
MH  - Silicon Dioxide/*chemistry
EDAT- 2013/10/17 06:00
MHDA- 2014/07/11 06:00
CRDT- 2013/10/17 06:00
PHST- 2013/10/17 06:00 [entrez]
PHST- 2013/10/17 06:00 [pubmed]
PHST- 2014/07/11 06:00 [medline]
AID - 10.1021/la4024986 [doi]
PST - ppublish
SO  - Langmuir. 2013 Nov 19;29(46):14274-83. doi: 10.1021/la4024986. Epub 2013 Nov 5.