PMID- 24128677
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20131022
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 72
IP  - 11
DP  - 2013 Nov
TI  - Neurotrophins in mesial temporal lobe epilepsy with and without psychiatric 
      comorbidities.
PG  - 1029-42
LID - 10.1097/NEN.0000000000000002 [doi]
AB  - Despite the strong association between epilepsy and psychiatric comorbidities, 
      data on clinicopathologic correlations are scant. We previously reported 
      differential mossy fiber sprouting (MFS) in mesial temporal lobe epilepsy (MTLE) 
      patients with psychosis (MTLE + P) and major depression (MTLE + D). Because 
      neurotrophins (NTs) can promote MFS, here, we investigated MFS, neuronal density 
      and immunoreactivity for the NT nerve growth factor (NGF), brain-derived 
      neurotrophic factor (BDNF) and neurotrophin 3 (NT3) in hippocampi of 14 MTLE 
      patients without a psychiatric history, 13 MTLE + D, 13 MTLE + P, and 10 control 
      necropsies. Mossy fiber sprouting correlated with granular layer NGF 
      immunoreactivity and seizure frequency. Patients with secondarily generalized 
      seizures exhibited less NGF immunoreactivity versus patients with complex partial 
      seizures. There was greater NT immunoreactivity in MTLE versus control groups but 
      lesser NT immunoreactivity in MTLE + P versus MTLE patients; these findings 
      correlated with neuropsychologic scores. Patients with MTLE + D taking fluoxetine 
      showed greater BDNF immunoreactivity than those not taking fluoxetine; MTLE + P 
      patients taking haloperidol had decreased neuronal density and immunoreactivity 
      for NGF and BDNF in specific subfields versus those not taking haloperidol. There 
      were no differences in NT3 immunoreactivity among the groups. These findings 
      support a close association between MFS and NT expression in the hippocampi of 
      MTLE patients and suggest that distinct structural and neurochemical milieu may 
      contribute to the genesis or maintenance of psychiatric comorbidities in MTLE.
FAU - Kandratavicius, Ludmyla
AU  - Kandratavicius L
AD  - From the Department of Neurosciences and Behavior, School of Medicine of Ribeirao 
      Preto, University of Sao Paulo, Sao Paulo, Brazil (LK, MRM, JEH, JPL); Center for 
      Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao 
      Paulo, Sao Paulo, Brazil (LK, JEH, JPL); National Institute of Science and 
      Technology in Translational Medicine (INCT-TM-CNPq), Brazil (JEH); Department of 
      Surgery, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao 
      Paulo, Brazil (JAA Jr., CGC Jr.).
FAU - Monteiro, Mariana Raquel
AU  - Monteiro MR
FAU - Assirati, Joao Alberto Jr
AU  - Assirati JA Jr
FAU - Carlotti, Carlos Gilberto Jr
AU  - Carlotti CG Jr
FAU - Hallak, Jaime Eduardo
AU  - Hallak JE
FAU - Leite, Joao Pereira
AU  - Leite JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder, Major/complications/metabolism/pathology
MH  - Epilepsy, Temporal Lobe/complications/*metabolism/pathology
MH  - Female
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*metabolism
MH  - Neurotrophin 3/*metabolism
MH  - Psychotic Disorders/complications/metabolism/pathology
EDAT- 2013/10/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/10/17 06:00
PHST- 2013/10/17 06:00 [entrez]
PHST- 2013/10/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1097/NEN.0000000000000002 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2013 Nov;72(11):1029-42. doi: 
      10.1097/NEN.0000000000000002.