PMID- 24129486
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20231206
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 73
IP  - 3
DP  - 2013
TI  - Ganglioside GM1 reduces white matter damage in neonatal rats.
PG  - 379-86
LID - 1944 [pii]
LID - 10.55782/ane-2013-1944 [doi]
AB  - This study investigated the neuronal protective effect of 
      monosialotetrahexosylganglioside (GM1) on the hypoxia-ischemia white matter 
      damage (WMD) in neonatal rats. Brain hypoxia-ischemia was induced by bilateral 
      carotid artery occlusion in 4-day-old neonatal rats. Bilateral carotid artery 
      occlusion (BCAO) was performed in rats in WMD and GM1 groups, while in sham 
      group; the rat bilateral carotid arteries were merely exposed without occlusion. 
      Immunohistochemical staining was used to determine the expression of myelin basic 
      protein (MBP), glial fibrillary acidic protein (GFAP), and beta-amyloid precursor 
      protein (beta-APP). In addition, suspension test, slope test, and open-field test 
      were carried out on day 26 after BCAO to determine the neurobehavioral function. 
      The percentage of MBP-positive cells was decreased while beta-APP-and 
      GFAPpositive cells were increased in WMD group. After treated with GM1, the 
      percentage of MBP-positive cells increased significantly than WMD rats at 
      post-operation 72 h and day 7. GFAP-positive cells and beta-APP-positive cells 
      decreased significantly in WMD group at post-operation 72 h, day 7 and 26. The 
      suspension test, slope test, and open-field test showed that neurobehavioral 
      function was improved in ganglioside GM1 group compared with WMD group. Taken 
      together, our findings suggested that ganglioside GM1 treatment reduces 
      hypoxia-ischemia induced impairment of the neurobehavioral function in WMD in 
      neonatal rats.
FAU - Rong, Xiao
AU  - Rong X
AD  - Department of Neonatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou Medical College, Guangzhou, China, zhouwei_pu02@126.com.
FAU - Zhou, Wei
AU  - Zhou W
FAU - Xiao-Wen, Chen
AU  - Xiao-Wen C
FAU - Tao, Li
AU  - Tao L
FAU - Tang, Juan
AU  - Tang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Myelin Basic Protein)
RN  - 37758-47-7 (G(M1) Ganglioside)
SB  - IM
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Carotid Artery Diseases/*complications
MH  - Disease Models, Animal
MH  - Female
MH  - G(M1) Ganglioside/*therapeutic use
MH  - Gene Expression Regulation/drug effects
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Leukoencephalopathies/*drug therapy/*etiology
MH  - Male
MH  - Myelin Basic Protein/metabolism
MH  - Neurons/drug effects/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2013/10/17 06:00
MHDA- 2014/04/22 06:00
CRDT- 2013/10/17 06:00
PHST- 2013/10/17 06:00 [entrez]
PHST- 2013/10/17 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - 1944 [pii]
AID - 10.55782/ane-2013-1944 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2013;73(3):379-86. doi: 10.55782/ane-2013-1944.