PMID- 24131017
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20131017
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 5
DP  - 2013 Nov
TI  - Actin cytoskeleton control of the comings and goings of T lymphocytes.
PG  - 301-11
LID - 10.1111/tan.12193 [doi]
AB  - T lymphocytes are key players of adaptive immune responses. Upon recognition of 
      specific peptides presented by human leukocyte antigen (HLA) molecules on antigen 
      presenting cells (APC), these cells execute subset-related functions such as 
      killing, help and regulation. The ontogeny, the activation and the effector 
      functions of T lymphocytes are all steps of T-lymphocyte life cycle that rely on 
      high motility properties. These cells travel through the organism in a succession 
      of steps, including entry into tissues, interstitial migration, APC scanning, 
      synapse formation and tissue exit. Such ability is possible because of a plastic 
      motility behavior, which is highly controlled in time and space. The molecular 
      basis for the adaptable motility behavior of T lymphocytes is only starting to be 
      unraveled. The scope of this review is to discuss recent data pointing to the key 
      role of regulators of actin cytoskeleton remodeling in tuning distinct aspects of 
      T-lymphocyte motility during their entry, residency and exit from tissues.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lafouresse, F
AU  - Lafouresse F
AD  - INSERM, U1043, Toulouse, France; Centre de Physiopathologie de Toulouse Purpan, 
      Universite Toulouse III Paul-Sabatier, Toulouse, France; CNRS, U5282, Toulouse, 
      France.
FAU - Vasconcelos, Z
AU  - Vasconcelos Z
FAU - Cotta-de-Almeida, V
AU  - Cotta-de-Almeida V
FAU - Dupre, L
AU  - Dupre L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130924
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
SB  - IM
MH  - Actin Cytoskeleton/*metabolism
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Cell Movement/immunology
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Lymphoid Tissue/cytology/immunology
MH  - T-Lymphocytes/cytology/*immunology
OTO - NOTNLM
OT  - T lymphocytes
OT  - actin cytoskeleton
OT  - migration
EDAT- 2013/10/18 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/10/18 06:00
PHST- 2013/10/18 06:00 [entrez]
PHST- 2013/10/18 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 10.1111/tan.12193 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Nov;82(5):301-11. doi: 10.1111/tan.12193. Epub 2013 Sep 24.