PMID- 24132524
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20211021
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 21
IP  - 4
DP  - 2014 Feb
TI  - Multi-biomarker responses in green mussels exposed to PFCs: effects at molecular, 
      cellular, and physiological levels.
PG  - 2785-94
LID - 10.1007/s11356-013-2216-6 [doi]
AB  - Perfluorinated chemicals (PFCs) are extremely persistent and have been found 
      extensively in the environment and wildlife. Oceans are the final sink for many 
      persistent organic pollutants (POPs) including PFCs. However, to date, there has 
      been a lack of studies that investigated the environmental consequences of PFCs 
      on marine organisms. To fill in this gap, environmental toxicity of two dominant 
      PFCs, perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), was 
      examined in a sentinel species, green mussel Perna viridis, using a series of 
      biomarkers corresponding to different biological levels (molecular, cellular, and 
      physiological). Correlations among these biomarkers were also investigated. The 
      results showed that the tested compounds can induce a series adverse effect at 
      different biological levels, including oxidative stress, DNA damage, membrane 
      instability, suppressed filtration rate, and reduced body weight. Correlation 
      analysis revealed that excess production of reactive oxygen species could be the 
      major toxic pathway. An indirect mode of toxic action was also explored where 
      adverse impacts could be secondary effects of PFC exposure. The joint analysis of 
      biomarkers from multiple biological levels resulted in a comprehensive 
      understanding of how PFC exposure can influence the health of organisms. The 
      correlations of these biomarkers also provided a new perspective of the 
      ecological consequences of PFCs.
FAU - Liu, Changhui
AU  - Liu C
AD  - School of Civil & Environmental Engineering, Nanyang Technological University, 50 
      Nanyang Avenue, Singapore, 639798, Singapore, C090079@ntu.edu.sg.
FAU - Gin, Karina Y H
AU  - Gin KY
FAU - Chang, Victor W C
AU  - Chang VW
LA  - eng
PT  - Journal Article
DEP - 20131017
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 0 (Water Pollutants, Chemical)
RN  - 261QK3SSBH (Neutral Red)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Caprylates/*toxicity
MH  - Catalase/metabolism
MH  - Comet Assay
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Fluorocarbons/*toxicity
MH  - Neutral Red/metabolism
MH  - Perna/*drug effects/metabolism
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2013/10/18 06:00
MHDA- 2014/06/06 06:00
CRDT- 2013/10/18 06:00
PHST- 2013/04/09 00:00 [received]
PHST- 2013/08/30 00:00 [accepted]
PHST- 2013/10/18 06:00 [entrez]
PHST- 2013/10/18 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
AID - 10.1007/s11356-013-2216-6 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2014 Feb;21(4):2785-94. doi: 
      10.1007/s11356-013-2216-6. Epub 2013 Oct 17.