PMID- 24132844 OWN - NLM STAT- MEDLINE DCOM- 20140519 LR - 20131017 IS - 1531-8257 (Electronic) IS - 0885-3185 (Linking) VI - 28 IP - 11 DP - 2013 Sep 15 TI - Higher-level gait disorders: an open frontier. PG - 1560-5 LID - 10.1002/mds.25673 [doi] AB - The term higher-level gait disorders (HLGD) defines a category of balance and gait disorders that are not explained by deficits in strength, tone, sensation, or coordination. HLGD are characterized by various combinations of disequilibrium and impaired locomotion. A plethora of new imaging techniques are beginning to determine the neural circuits that are the basis of these disorders. Although a variety of neurodegenerative and other pathologies can produce HLGD, the most common cause appears to be microvascular disease that causes white-matter lesions and thereby disrupts balance/locomotor circuits. CI - (c) 2013 Movement Disorder Society. FAU - Nutt, John G AU - Nutt JG AD - Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Mov Disord JT - Movement disorders : official journal of the Movement Disorder Society JID - 8610688 SB - IM MH - Gait Disorders, Neurologic/*classification/diagnosis/*physiopathology MH - Humans MH - Locomotion MH - Neuroimaging MH - Psychomotor Performance OTO - NOTNLM OT - balance OT - falls OT - gait OT - gait disorders OT - locomotor circuits EDAT- 2013/10/18 06:00 MHDA- 2014/05/20 06:00 CRDT- 2013/10/18 06:00 PHST- 2013/04/11 00:00 [received] PHST- 2013/07/26 00:00 [revised] PHST- 2013/08/13 00:00 [accepted] PHST- 2013/10/18 06:00 [entrez] PHST- 2013/10/18 06:00 [pubmed] PHST- 2014/05/20 06:00 [medline] AID - 10.1002/mds.25673 [doi] PST - ppublish SO - Mov Disord. 2013 Sep 15;28(11):1560-5. doi: 10.1002/mds.25673.