PMID- 24133043
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20181202
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 102
IP  - 9
DP  - 2014 Sep
TI  - Synthesis, characterization, and biocompatibility of alternating block 
      polyurethanes based on PLA and PEG.
PG  - 3243-54
AB  - A series of alternating block polyurethanes (abbreviated as PULA-alt-PEG) and 
      random block polyurethanes (abbreviated as PULA-ran-PEG) based on poly(L-lactic 
      acid) (PLA) and poly(ethylene glycol) (PEG) were synthesized. The differences of 
      PULA-alt/ran-PEG chemical structure, molecular weight, distribution, thermal 
      properties, mechanical properties and static contact angle were systematically 
      investigated. The PULA-alt/ran-PEG polyurethanes exhibited low T(g) (-47.3  approximately  
      -34.4 degrees C), wide mechanical properties (stress sigma(t): 4.6-32.6 MPa, modulus E: 
      11.4-323.9 MPa and strain epsilon: 468-1530%) and low water contact angle (35.4-51.4 degrees ). 
      Scanning electron microscope (SEM) observation showed that PULA-alt-PEG film 
      displays rougher and more patterned surface morphology than PULA-ran-PEG does, 
      due to more regular structures of PULA-alt-PEG. Hydrolytic degradation shows that 
      degradation rate of random block polyurethane series PULA-ran-PEG is higher than 
      the alternating counterpart PULA-alt-PEG. PLA segment degradation is faster than 
      urethane linkage and PEG segment almost does not degrade in the buffer solution. 
      Platelet adhesion study showed that all the polyurethanes possess excellent 
      hemocompatibility. The cell culture assay revealed that PULA-alt/ran-PEG 
      polyurethanes were cell inert and unfavorable for the attachment of rat glial 
      cell due to the hydrophilic characters of the materials.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Mei, Tingzhen
AU  - Mei T
FAU - Zhu, Yonghe
AU  - Zhu Y
FAU - Ma, Tongcui
AU  - Ma T
FAU - He, Tao
AU  - He T
FAU - Li, Linjing
AU  - Li L
FAU - Wei, Chiju
AU  - Wei C
FAU - Xu, Kaitian
AU  - Xu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 0 (Polyurethanes)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemical synthesis/*chemistry/metabolism
MH  - Cells, Cultured
MH  - Humans
MH  - Hydrolysis
MH  - Lactic Acid/chemical synthesis/*chemistry/metabolism
MH  - Materials Testing
MH  - Neuroglia/cytology
MH  - Platelet Adhesiveness
MH  - Polyesters
MH  - Polyethylene Glycols/chemical synthesis/*chemistry/metabolism
MH  - Polymers/chemical synthesis/*chemistry/metabolism
MH  - Polyurethanes/chemical synthesis/*chemistry/metabolism
MH  - Rats
MH  - Surface Properties
EDAT- 2013/10/18 06:00
MHDA- 2015/03/31 06:00
CRDT- 2013/10/18 06:00
PHST- 2013/08/26 00:00 [received]
PHST- 2013/10/09 00:00 [revised]
PHST- 2013/10/11 00:00 [accepted]
PHST- 2013/10/18 06:00 [entrez]
PHST- 2013/10/18 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1002/jbma.35004 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2014 Sep;102(9):3243-54. doi: 10.1002/jbma.35004.