PMID- 24133584
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 6
IP  - 10
DP  - 2013
TI  - Upregulation of ATF-3 is correlated with prognosis and proliferation of laryngeal 
      cancer by regulating Cyclin D1 expression.
PG  - 2064-70
AB  - OBJECTIVE: This study aimed to investigate the expression and significance of 
      ATF-3 in laryngeal squamous cell carcinoma (LSCC). METHODS: Expression of ATF-3 
      was examined using immunohistochemistry methods in samples from 83 cases of LSCC 
      carcinoma. MTT assay was used to detect proliferation of Hep-2 cells after ATF-3 
      knocked down by siRNA lentivirus. A mouse model was used to investigate the 
      inhibitive role of ATF-3 siRNA in LSCC xenografts. Realtime RCR was used to 
      detect Cyclin D1 expression after ATF-3 downregulation in Hep-2 cells. RESULTS: 
      The expression of ATF-3 was positively detected in all the 83 cases of LSCC 
      cancer tissues while Only 4 cases of adjacent non-neoplastic tissues were 
      detected with positive ATF-3 expression. The ATF-3 expression was statistically 
      related with T stage, neck nodal metastasis, clinical stage and prognosis of 
      LSCC. Both cell proliferation in vitro and tumor growth in vivo were suppressed 
      after ATF-3 knockdown. Furthermore, the expression of Cyclin D1 was decreased 
      after ATF-3 downregulation in Hep-2 cells. CONCLUSION: ATF-3 is involved in the 
      progress of LSCC, and may provide clinical information for evaluation of 
      prognosis of LSCC. The oncologic role of ATF-3 may be correlated with Cyclin D1 
      regulation.
FAU - Feng, Jiapeng
AU  - Feng J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Sun, Qingfeng
AU  - Sun Q
FAU - Wu, Tianyi
AU  - Wu T
FAU - Lu, Jianguang
AU  - Lu J
FAU - Qu, Lingmei
AU  - Qu L
FAU - Sun, Yanan
AU  - Sun Y
FAU - Tian, Linli
AU  - Tian L
FAU - Zhang, Binghui
AU  - Zhang B
FAU - Li, Dandan
AU  - Li D
FAU - Liu, Ming
AU  - Liu M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130915
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (ATF3 protein, human)
RN  - 0 (Activating Transcription Factor 3)
RN  - 0 (RNA, Small Interfering)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Activating Transcription Factor 3/genetics/*metabolism
MH  - Animals
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cyclin D1/genetics/*metabolism
MH  - Down-Regulation
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Prognosis
MH  - RNA, Small Interfering
MH  - *Up-Regulation
PMC - PMC3796228
OTO - NOTNLM
OT  - Cyclin D1
OT  - Laryngeal squamous cell carcinoma
OT  - activating transcription factor 3
EDAT- 2013/10/18 06:00
MHDA- 2014/06/10 06:00
PMCR- 2013/09/15
CRDT- 2013/10/18 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2013/08/21 00:00 [accepted]
PHST- 2013/10/18 06:00 [entrez]
PHST- 2013/10/18 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2013/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2013 Sep 15;6(10):2064-70. eCollection 2013.