PMID- 24133900
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20191112
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 59
IP  - 7-8
DP  - 2013
TI  - Heparin-induced thrombocytopenia in Chinese patients: 240 patients study in one 
      center.
PG  - 735-40
AB  - BACKGROUND: The study was conducted in order to analyze the incidence of 
      heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia and 
      thrombosis syndrome (HITTS) in 240 patients from the Department of Vascular 
      Surgery in China, to evaluate the current laboratory detection technique, and to 
      explore the feasibility for the technique to be developed in China. METHODS: 240 
      patients receiving unfractionated heparin (UFH) were studied in one center. 
      Before and after the UFH treatment, platelet count, HIT-antibody ELISA test, and 
      heparin-induced platelet aggregation (HIPA) were tested. RESULTS: Among 240 
      patients, HIT was diagnosed in 36 cases. The incidence was 15%. HITTS occurred in 
      6 cases (2.5%). The median time of thrombocytopenia was the 8th day. Platelet 
      counts recovered to normal level in 3 - 6 days after heparin withdrawal 
      CONCLUSIONS: The incidence of HIT is higher; however, the incidence of HITTS is 
      lower. Monitoring platelet count, which is simple and easy to do and available in 
      hospitals at different levels (township hospital included), is a reliable method 
      to diagnose HIT early. The HIT-antibody ELISA test could be introduced in 
      specific hospitals to prescreen HIT. In view of the higher sensitivity and 
      specificity of HIPA, it can be used in larger diagnostic centers in all the big 
      cities of China.
FAU - Wang, Jinghua
AU  - Wang J
AD  - Department of Hematology, Second Affiliated Hospital, Harbin Medical University, 
      Harbin 150081, China. jinghuawangcn@126.com
FAU - Dong, Xiushuai
AU  - Dong X
FAU - Xin, Yan
AU  - Xin Y
FAU - Xu, Ping
AU  - Xu P
FAU - Xue, Yanming
AU  - Xue Y
FAU - Wang, Longyan
AU  - Wang L
FAU - Wang, Ying
AU  - Wang Y
FAU - Wang, Chunying
AU  - Wang C
FAU - Chen, Xi
AU  - Chen X
FAU - Guan, Yue
AU  - Guan Y
FAU - Liu, Juan
AU  - Liu J
FAU - Chang, Yuying
AU  - Chang Y
FAU - Gao, Xinyu
AU  - Gao X
FAU - Jin, Yinglan
AU  - Jin Y
FAU - Zhang, Yanqing
AU  - Zhang Y
FAU - Li, Xiaoyun
AU  - Li X
FAU - Dai, Haibin
AU  - Dai H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Activation
MH  - Thrombocytopenia/*chemically induced
EDAT- 2013/10/19 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - 10.7754/clin.lab.2012.120701 [doi]
PST - ppublish
SO  - Clin Lab. 2013;59(7-8):735-40. doi: 10.7754/clin.lab.2012.120701.