PMID- 24133925
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20191112
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 59
IP  - 7-8
DP  - 2013
TI  - Evaluation of three APTT reagents in a routine laboratory: toward a compromise.
PG  - 921-4
AB  - BACKGROUND: Our current activated partial thromboplastin time (APTT) reagent 
      (PTT-A) is often prolonged for unexplained reasons. METHODS: We decided to 
      compare this reagent with an alternative reagent (Cephascreen) and with our 
      second line APTT (Actin FS) in terms of cut-off values, sensitivity to in-vitro 
      coagulation factor deficiencies, sensitivity to lupus anticoagulant (LA), and in 
      vivo sensitivity to unfractionated heparin (UFH). RESULTS: Actin FS, PTT-A, and 
      Cephascreen were prolonged for FVIII level at 60%, 40%, and 40% respectively, FIX 
      at 50%, 25%, and 35%, and FXI at 60%, 20%, and 50%. PTT-A showed the same 
      sensitivity and specificity as Cephascreen to LA. Actin FS and PTT-A appeared 
      less suitable to monitor UFH regarding the CLSI criteria. CONCLUSIONS: 
      Cephascreen fulfilled the CLSI performance criteria, with a good compromise in 
      terms of sensitivity to factor deficiency and with a substantial reduction of 
      complementary analysis in our routine practice.
FAU - Rozen, Laurence
AU  - Rozen L
AD  - Laboratory of Hematology and Haemostasis, Centre Hospitalier Universitaire 
      Brugmann, Brussels, Belgium. laurence.rozen@chu-brugmann.be
FAU - Copette, Florian
AU  - Copette F
FAU - Noubouossie, Denis F
AU  - Noubouossie DF
FAU - Demulder, Anne
AU  - Demulder A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Indicators and Reagents)
SB  - IM
MH  - Humans
MH  - *Indicators and Reagents
MH  - *Partial Thromboplastin Time
EDAT- 2013/10/19 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - 10.7754/clin.lab.2012.120909 [doi]
PST - ppublish
SO  - Clin Lab. 2013;59(7-8):921-4. doi: 10.7754/clin.lab.2012.120909.