PMID- 24134405
OWN - NLM
STAT- MEDLINE
DCOM- 20151013
LR  - 20140804
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 27
IP  - 13
DP  - 2014 Sep
TI  - Single dose recombinant erythropoietin versus moderate hypothermia for neonatal 
      hypoxic ischemic encephalopathy in low resource settings.
PG  - 1295-300
LID - 10.3109/14767058.2013.855894 [doi]
AB  - OBJECTIVE: To determine the safety and efficacy of single dose systemic 
      recombinant human erythropoietin (rEPO) in neonates with perinatal hypoxic 
      Ischemic Encephalopathy (HIE), and its effect on serum brain-derived neurotrophic 
      factor (BDNF) and neuron-specific enolase (NSE). METHODS: Forty-five full-term 
      neonates; 30 with perinatal HIE and 15 controls were studied. HIE neonates were 
      randomized into three intervention groups (first 6 h of life): 10 received single 
      subcutaneous 1500 U/kg rEPO at day-1, 10 subjected to hypothermia for 72 h and 10 
      received supportive care. BDNF and NSE measured during first 6 h and day 5 
      postnatal. Daily Thompson's score, MRI brain and neuromuscular function scale for 
      survivors at 3 months of age were done. RESULTS: Hypothermia group had best 
      survival especially with stage-II Sarnat scale, followed by rEpo and supportive 
      group. BDNF day-5 was significantly higher in each group compared to controls. 
      MRI score and neuromuscular function score were non-significantly lower in the 
      hypothermia group compared to rEPO. CONCLUSIONS: Therapeutic hypothermia was 
      superior to single dose rEpo for neuro-protection in HIE especially in patients 
      with stage-II Sarnat scale. Therapeutic effect of combined rEPO multiple dosing 
      and modest hypothermia therapy should be studied.
FAU - El Shimi, M Sami
AU  - El Shimi MS
AD  - Department of Paediatrics and.
FAU - Awad, Hisham A
AU  - Awad HA
FAU - Hassanein, Sahar M A
AU  - Hassanein SM
FAU - Gad, Ghada I
AU  - Gad GI
FAU - Imam, Safaa S
AU  - Imam SS
FAU - Shaaban, Hebatallah A
AU  - Shaaban HA
FAU - El Maraghy, Mohamed O
AU  - El Maraghy MO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20131113
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Case-Control Studies
MH  - *Developing Countries
MH  - Erythropoietin/*administration & dosage
MH  - Female
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Hypoxia-Ischemia, Brain/*drug therapy
MH  - Infant, Newborn
MH  - Male
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - erythropoietin
OT  - hypothermia
OT  - neurone-specific enolase
OT  - perinatal hypoxia
EDAT- 2013/10/19 06:00
MHDA- 2015/10/16 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.3109/14767058.2013.855894 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2014 Sep;27(13):1295-300. doi: 
      10.3109/14767058.2013.855894. Epub 2013 Nov 13.