PMID- 24134520
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20211021
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Oct 17
TI  - Alterations in regional homogeneity assessed by fMRI in patients with migraine 
      without aura stratified by disease duration.
PG  - 85
LID - 10.1186/1129-2377-14-85 [doi]
AB  - BACKGROUND: Advanced neuroimaging approaches have been employed to prove that 
      migraine was a central nervous system disorder. This study aims to examine 
      resting-state abnormalities in migraine without aura (MWoA) patients stratified 
      by disease duration, and to explore the neuroimaging markers for reflecting the 
      disease duration. METHODS: 40 eligible MWoA patients and 20 matched healthy 
      volunteers were included in the study. Regional homogeneity (ReHo) analysis was 
      used to identify the local features of spontaneous brain activity in MWoA 
      patients stratified by disease duration, and analysis was performed to 
      investigate the correlation of overlapped brain dysfunction in MWoA patients with 
      different disease duration (long-term and short-term) and course of disease. 
      RESULTS: Compared with healthy controls, MWoA patients with long-term disease 
      duration showed comprehensive neuronal dysfunction than patients with short-term 
      disease duration. In addition, increased average ReHo values in the thalamus, 
      brain stem, and temporal pole showed significantly positive correlations with the 
      disease duration. On the contrary, ReHo values were negatively correlated with 
      the duration of disease in the anterior cingulate cortex, insula, posterior 
      cingulate cortex and superior occipital gyrus. CONCLUSIONS: Our findings of 
      progressive brain damage in relation to increasing disease duration suggest that 
      migraine without aura is a progressive central nervous disease, and the length of 
      the disease duration was one of the key reasons to cause brain dysfunction in 
      MwoA patients. The repeated migraine attacks over time result in resting-state 
      abnormalities of selective brain regions belonging to the pain processing and 
      cognition. We predict that these brain regions are sensitive neuroimaging markers 
      for reflecting the disease duration of migraine patients without aura.
FAU - Zhao, Ling
AU  - Zhao L
FAU - Liu, Jixin
AU  - Liu J
FAU - Dong, Xilin
AU  - Dong X
FAU - Peng, Yulin
AU  - Peng Y
FAU - Yuan, Kai
AU  - Yuan K
FAU - Wu, Fumei
AU  - Wu F
FAU - Sun, Jinbo
AU  - Sun J
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Qin, Wei
AU  - Qin W
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan 610075, China. chinwei@mail.xidian.edu.cn.
FAU - Liang, Fanrong
AU  - Liang F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131017
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
SB  - IM
MH  - Adult
MH  - Brain/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Migraine without Aura/*pathology
PMC - PMC3853130
EDAT- 2013/10/19 06:00
MHDA- 2014/05/13 06:00
PMCR- 2013/01/01
CRDT- 2013/10/19 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2013/10/04 00:00 [accepted]
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 1129-2377-14-85 [pii]
AID - 10.1186/1129-2377-14-85 [doi]
PST - epublish
SO  - J Headache Pain. 2013 Oct 17;14(1):85. doi: 10.1186/1129-2377-14-85.