PMID- 24135079
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20220331
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 22
IP  - 14
DP  - 2013 Dec
TI  - Depression in systemic lupus erythematosus, dependent on or independent of 
      severity of disease.
PG  - 1462-9
LID - 10.1177/0961203313508443 [doi]
AB  - OBJECTIVES: To estimate the prevalence of depression in subjects with systemic 
      lupus erythematosus (SLE) in relation to the general population and to unravel 
      the relation between depression and SLE disease characteristics. METHODS: One 
      hundred and two subjects with SLE (mean age 44.4 years) were studied using the 
      Beck Depression Inventory (BDI) score to estimate the prevalence of depression. 
      The BDI scores in subjects with SLE were compared with BDI scores from a 
      pan-European population based study (Outcome in Depression International Network 
      (ODIN) study, n = 7934), i.e. the general population. RESULTS: The mean BDI score 
      was higher in SLE subjects (10.1 points) compared with the BDI scores derived 
      from the general population (10.1 versus 5.6 points, respectively, p < 0.001). 
      This corresponds to a prevalence of depression of 16.6% and 6.7%, respectively. 
      There was no association between disease activity or organ damage and BDI scores 
      in subjects with SLE (p > 0.1). Only 7% of SLE subjects with high BDI scores used 
      antidepressants. CONCLUSION: The mean BDI score and prevalence of depression are 
      significantly higher in SLE subjects compared with the general population. No 
      association was found between SLE disease characteristics and BDI scores. The 
      number of depressed SLE subjects treated with antidepressants is low, suggesting 
      inadequate recognition and treatment of depression in SLE.
FAU - van Exel, E
AU  - van Exel E
AD  - 1Department of Psychiatry, VU University Medical Center, the Netherlands.
FAU - Jacobs, J
AU  - Jacobs J
FAU - Korswagen, L-A
AU  - Korswagen LA
FAU - Voskuyl, A E
AU  - Voskuyl AE
FAU - Stek, M
AU  - Stek M
FAU - Dekker, J
AU  - Dekker J
FAU - Bultink, I E M
AU  - Bultink IE
LA  - eng
PT  - Journal Article
DEP - 20131017
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/administration & dosage/*therapeutic use
MH  - Depression/drug therapy/*epidemiology
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Systemic lupus erythematosus
OT  - depression
OT  - disease activity
EDAT- 2013/10/19 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
AID - 0961203313508443 [pii]
AID - 10.1177/0961203313508443 [doi]
PST - ppublish
SO  - Lupus. 2013 Dec;22(14):1462-9. doi: 10.1177/0961203313508443. Epub 2013 Oct 17.