PMID- 24135451
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20171116
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 162
IP  - 4
DP  - 2013
TI  - An increased number of CD4+CD25+ cells induced by an oral administration of 
      Lactobacillus plantarum NRIC0380 are involved in antiallergic activity.
PG  - 283-9
LID - 10.1159/000354924 [doi]
AB  - BACKGROUND: Our previous study showed that an oral administration of 
      Lactobacillus plantarum NRIC0380 inhibited immunoglobulin E (IgE) production in a 
      murine model, and that orally administered NRIC0380 induced CD4+CD25+ Foxp3+ T, 
      i.e. regulatory T (Treg), cells in the spleen and Peyer's patch of mice. Although 
      it has been reported that Treg cells might suppress the allergic symptoms, the 
      involvement of the cells in the antiallergic activity of lactic acid bacteria has 
      not been clearly demonstrated. We therefore examined in detail the antiallergic 
      activity of Treg cells obtained from mice that had been fed NRIC0380. METHODS: 
      Treg cells were obtained from mice that had been fed NRIC0380. The T 
      cell-suppressive effect of the cells was analyzed by coculturing the cells with 
      splenocytes of beta-lactoglobulin-immunized mice and beta-lactoglobulin. The effects of 
      the Treg cells on the IgE production and cutaneous anaphylaxis reaction were then 
      analyzed by transferring the cells into another mouse. RESULTS: The Treg cells 
      obtained from the mice that had been fed NRIC0380 showed similar T 
      cell-suppressive activity to those cells obtained from the control mice. The Treg 
      cells obtained from the mice fed NRIC0380 significantly inhibited the IgE 
      production and active cutaneous anaphylaxis reaction when transferred into 
      another mouse that was subsequently immunized with the antigen. Furthermore, the 
      Treg cells also significantly suppressed the passive cutaneous anaphylaxis 
      reaction when cotransferred with the IgE antibody into another mouse. 
      CONCLUSIONS: The induction of Treg cells by the oral administration of NRIC0380 
      would be involved in the antiallergic activity of NRIC0380.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Yoshida, Tadashi
AU  - Yoshida T
AD  - Department of Applied Biological Science, Tokyo University of Agriculture and 
      Technology, Tokyo, Japan.
FAU - Fujiwara, Wataru
AU  - Fujiwara W
FAU - Enomoto, Mai
AU  - Enomoto M
FAU - Nakayama, Sayuri
AU  - Nakayama S
FAU - Matsuda, Hiroshi
AU  - Matsuda H
FAU - Sugiyama, Hisashi
AU  - Sugiyama H
FAU - Shimojoh, Manabu
AU  - Shimojoh M
FAU - Okada, Sanae
AU  - Okada S
FAU - Hattori, Makoto
AU  - Hattori M
LA  - eng
PT  - Journal Article
DEP - 20131017
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (CD4 Antigens)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Allergic Agents/*administration & dosage/immunology
MH  - CD4 Antigens/metabolism
MH  - Immunoglobulin E/biosynthesis/immunology
MH  - Interleukin-2 Receptor alpha Subunit/metabolism
MH  - Lactobacillus plantarum/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis
MH  - Probiotics/*administration & dosage
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2013/10/19 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/03/13 00:00 [received]
PHST- 2013/07/15 00:00 [accepted]
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - 000354924 [pii]
AID - 10.1159/000354924 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;162(4):283-9. doi: 10.1159/000354924. Epub 2013 
      Oct 17.