PMID- 24135755
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211021
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 54
IP  - 12
DP  - 2013 Nov 15
TI  - Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes 
      with nonneovascular age-related macular degeneration.
PG  - 7498-509
LID - 10.1167/iovs.13-12433 [doi]
AB  - PURPOSE: To evaluate cone spacing using adaptive optics scanning laser 
      ophthalmoscopy (AOSLO) in eyes with nonneovascular AMD, and to correlate 
      progression of AOSLO-derived cone measures with standard measures of macular 
      structure. METHODS: Adaptive optics scanning laser ophthalmoscopy images were 
      obtained over 12 to 21 months from seven patients with AMD including four eyes 
      with geographic atrophy (GA) and four eyes with drusen. Adaptive optics scanning 
      laser ophthalmoscopy images were overlaid with color, infrared, and 
      autofluorescence fundus photographs and spectral domain optical coherence 
      tomography (SD-OCT) images to allow direct correlation of cone parameters with 
      macular structure. Cone spacing was measured for each visit in selected regions 
      including areas over drusen (n = 29), at GA margins (n = 14), and regions without 
      drusen or GA (n = 13) and compared with normal, age-similar values. RESULTS: 
      Adaptive optics scanning laser ophthalmoscopy imaging revealed continuous cone 
      mosaics up to the GA edge and overlying drusen, although reduced cone 
      reflectivity often resulted in hyporeflective AOSLO signals at these locations. 
      Baseline cone spacing measures were normal in 13/13 unaffected regions, 26/28 
      drusen regions, and 12/14 GA margin regions. Although standard clinical measures 
      showed progression of GA in all study eyes, cone spacing remained within normal 
      ranges in most drusen regions and all GA margin regions. CONCLUSIONS: Adaptive 
      optics scanning laser ophthalmoscopy provides adequate resolution for 
      quantitative measurement of cone spacing at the margin of GA and over drusen in 
      eyes with AMD. Although cone spacing was often normal at baseline and remained 
      normal over time, these regions showed focal areas of decreased cone 
      reflectivity. These findings may provide insight into the pathophysiology of AMD 
      progression. (ClinicalTrials.gov number, NCT00254605).
FAU - Zayit-Soudry, Shiri
AU  - Zayit-Soudry S
AD  - Department of Ophthalmology, University of California at San Francisco, San 
      Francisco, California.
FAU - Duncan, Jacque L
AU  - Duncan JL
FAU - Syed, Reema
AU  - Syed R
FAU - Menghini, Moreno
AU  - Menghini M
FAU - Roorda, Austin J
AU  - Roorda AJ
LA  - eng
SI  - ClinicalTrials.gov/NCT00254605
GR  - P30 EY002162/EY/NEI NIH HHS/United States
GR  - R01 EY014375/EY/NEI NIH HHS/United States
GR  - EY014375/EY/NEI NIH HHS/United States
GR  - EY002162/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131115
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Geographic Atrophy/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Retinal Cone Photoreceptor Cells/*pathology
MH  - Retinal Drusen/*diagnosis
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
PMC - PMC3832216
OTO - NOTNLM
OT  - adaptive optics
OT  - age-related macular degeneration
OT  - cones
OT  - scanning laser ophthalmoscopy
EDAT- 2013/10/19 06:00
MHDA- 2014/01/25 06:00
PMCR- 2014/05/01
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - iovs.13-12433 [pii]
AID - 10.1167/iovs.13-12433 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7498-509. doi: 
      10.1167/iovs.13-12433.