PMID- 24135757
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20131125
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 54
IP  - 12
DP  - 2013 Nov 21
TI  - Retinal nerve fiber layer structure abnormalities in schizophrenia and its 
      relationship to disease state: evidence from optical coherence tomography.
PG  - 7785-92
LID - 10.1167/iovs.13-12534 [doi]
AB  - PURPOSE: We determined structural retinal nerve fiber layer (RNFL) changes in 
      schizophrenia patients and established if the structural changes were related to 
      the duration of the illness using spectral-domain optical coherence tomography 
      (SD-OCT). METHODS: We recruited a total of 30 schizophrenic patients and 30 
      age-matched controls in the study. The schizophrenic patients were subdivided 
      further to acute (n = 5), chronic (n = 13), and long-term chronic (n = 12) 
      subgroups depending on their duration of illness. Using SD-OCT, the peripapillary 
      RNFL thickness, macula thickness, and macula volume measurements of schizophrenic 
      patients and the control subjects were measured and compared at each location. 
      RESULTS: Schizophrenic patients showed a statistically significant reduction in 
      overall peripapillary RNFL thickness (cases, 94.70 +/- 9.88 mum; controls, 103.53 +/- 
      6.53 mum; P < 0.001), macula thickness (cases, 269.26 +/- 12.59 mum; controls, 284.83 
      +/- 9.76 mum; P < 0.001), and macula volume (cases, 9.61 +/- 0.45 mm(3); controls, 
      10.17 +/- 0.35 mum; P < 0.001). Chronic and long-term chronic schizophrenic patients 
      were found to have significant peripapillary RNFL thinning, macula thinning, and 
      reduction of macula volume when compared to controls (P < 0.001). There also was 
      a statistically significant reverse correlation (P < 0.05) of peripapillary RNFL 
      thickness (r = -0.36), macula thickness (r = -0.38), and macula volume reduction 
      (r = -0.36) with the duration of schizophrenic illness. CONCLUSIONS: These 
      results indicate that RNFL and macula thickness, as well as macula volume 
      measurements are reduced in schizophrenic patients. The degree of thinning and 
      reduction was more significant in the chronic phase of the disease and correlated 
      with the duration of illness. These findings demonstrate that SD-OCT can be a 
      useful tool for the diagnosis and monitoring the progression of this disease.
FAU - Lee, Wei Wei
AU  - Lee WW
AD  - Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Tajunisah, Iqbal
AU  - Tajunisah I
FAU - Sharmilla, Kanagasundram
AU  - Sharmilla K
FAU - Peyman, Mohammadreza
AU  - Peyman M
FAU - Subrayan, Visvaraja
AU  - Subrayan V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131121
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Prospective Studies
MH  - Retinal Diseases/complications/*diagnosis/physiopathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Schizophrenia/*complications
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
OTO - NOTNLM
OT  - SD-OCT
OT  - duration of illness
OT  - retinal nerve fiber layer
OT  - schizophrenia
EDAT- 2013/10/19 06:00
MHDA- 2014/01/10 06:00
CRDT- 2013/10/19 06:00
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
AID - iovs.13-12534 [pii]
AID - 10.1167/iovs.13-12534 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2013 Nov 21;54(12):7785-92. doi: 
      10.1167/iovs.13-12534.