PMID- 24137066 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20131018 LR - 20211021 IS - 1303-2968 (Print) IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 11 IP - 1 DP - 2012 TI - Different circulating brain-derived neurotrophic factor responses to acute exercise between physically active and sedentary subjects. PG - 83-8 AB - Although circulating brain-derived neurotrophic factor (BDNF) level is affected by both acute and chronic physical activity, the interaction of acute and chronic physical activity was still unclear. In this study, we compared the serum and plasma BDNF responses to maximal and submaximal acute exercises between physically active and sedentary subjects. Eight active and 8 sedentary female subjects participated in the present study. Both groups performed 3 exercise tests with different intensities, i.e. 100% (maximal), 60% (moderate) and 40% (low) of their peak oxygen uptake. In each exercise test, blood samples were taken at the baseline and immediately, 30 and 60 min after the test. The serum BDNF concentration was found to significantly increase immediately after maximal and moderate exercise tests in both groups. In maximal exercise test, the pattern of change in the serum BDNF concentration was different between the groups. While the serum BDNF level for the sedentary group returned to the baseline level during the recovery phase, the BDNF levels for the active group decreased below the baseline level after the maximal exercise test. No group differences were observed in the pattern of plasma BDNF change for all exercise tests. These findings suggest that regular exercise facilitates the utilization of circulating BDNF during and/or after acute exercise with maximal intensity. KEY POINTS: In maximal exercise test, the pattern of change in the serum BDNF concentration was different between the groups.While the serum BDNF level for the sedentary group returned to the baseline level during the recovery phase, the BDNF levels for the active group decreased below the baseline level after the maximal exercise test.No group differences were observed in the pattern of serum BDNF change for moderate or low exercise tests.No group differences were observed in the pattern of plasma BDNF change for all exercise tests. FAU - Nofuji, Yu AU - Nofuji Y AD - Institute of Health Science, Kyushu University, Kasuga , Fukuoka, Japan. FAU - Suwa, Masataka AU - Suwa M FAU - Sasaki, Haruka AU - Sasaki H FAU - Ichimiya, Atsushi AU - Ichimiya A FAU - Nishichi, Reiko AU - Nishichi R FAU - Kumagai, Shuzo AU - Kumagai S LA - eng PT - Journal Article DEP - 20120301 PL - Turkey TA - J Sports Sci Med JT - Journal of sports science & medicine JID - 101174629 PMC - PMC3737858 OTO - NOTNLM OT - Serum BDNF OT - acute exercise OT - plasma BDNF EDAT- 2012/01/01 00:00 MHDA- 2012/01/01 00:01 PMCR- 2012/03/01 CRDT- 2013/10/19 06:00 PHST- 2011/10/10 00:00 [received] PHST- 2011/12/19 00:00 [accepted] PHST- 2013/10/19 06:00 [entrez] PHST- 2012/01/01 00:00 [pubmed] PHST- 2012/01/01 00:01 [medline] PHST- 2012/03/01 00:00 [pmc-release] AID - jssm-11-83 [pii] PST - epublish SO - J Sports Sci Med. 2012 Mar 1;11(1):83-8. eCollection 2012.