PMID- 24137162
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131018
LR  - 20220129
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013
TI  - CD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human 
      Colonic Mucosa.
PG  - 307
LID - 10.3389/fimmu.2013.00307 [doi]
LID - 307
AB  - Immune responses at the intestinal mucosa must allow for host protection whilst 
      simultaneously avoiding inappropriate inflammation. Although much work has 
      focused on the innate immune functionality of hematopoietic immune cells, 
      non-hematopoietic cell populations - including epithelial and stromal cells - are 
      now recognized as playing a key role in innate defense at this site. In this 
      study we examined the innate immune capacity of primary human intestinal stromal 
      cells (iSCs). CD90(+) iSCs isolated from human colonic mucosa expressed a wide 
      array of innate immune receptors and functionally responded to stimulation with 
      bacterial ligands. iSCs also sensed infection with live Salmonella typhimurium, 
      rapidly expressing IL-1 family cytokines via a RIPK2/p38MAPK-dependent signaling 
      process. In addition to responding to innate immune triggers, primary iSCs 
      exhibited a capacity for bacterial uptake, phagocytosis, and antigen processing, 
      although to a lesser extent than professional APCs. Thus CD90(+) iSCs represent 
      an abundant population of "non-professional" innate immune effector cells of the 
      human colonic mucosa and likely play an important adjunctive role in host defense 
      and immune regulation at this site.
FAU - Owens, Benjamin M J
AU  - Owens BM
AD  - Translational Gastroenterology Unit, Nuffield Department of Medicine, 
      Experimental Medicine Division, John Radcliffe Hospital, University of Oxford , 
      Oxford , UK.
FAU - Steevels, Tessa A M
AU  - Steevels TA
FAU - Dudek, Michael
AU  - Dudek M
FAU - Walcott, David
AU  - Walcott D
FAU - Sun, Mei-Yi
AU  - Sun MY
FAU - Mayer, Alice
AU  - Mayer A
FAU - Allan, Philip
AU  - Allan P
FAU - Simmons, Alison
AU  - Simmons A
LA  - eng
GR  - 102974/Wellcome Trust/United Kingdom
GR  - NIHR-RP-R3-12-026/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20130930
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
EIN - Front Immunol. 2015;6:325. PMID: 26157441
PMC - PMC3786311
OTO - NOTNLM
OT  - innate immunity
OT  - intestinal homeostasis
OT  - mucosal immunology
OT  - stromal cells
EDAT- 2013/10/19 06:00
MHDA- 2013/10/19 06:01
PMCR- 2013/01/01
CRDT- 2013/10/19 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2013/09/13 00:00 [accepted]
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2013/10/19 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00307 [doi]
PST - epublish
SO  - Front Immunol. 2013 Sep 30;4:307. doi: 10.3389/fimmu.2013.00307. eCollection 
      2013.