PMID- 2413720
OWN - NLM
STAT- MEDLINE
DCOM- 19851118
LR  - 20181130
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 125
IP  - 1
DP  - 1985 Sep
TI  - Histamine: the sole mediator of pentagastrin-stimulated acid secretion.
PG  - 135-43
AB  - Isolated frog gastric mucosa was used to study the effect of pentagastrin on 
      histamine release and acid secretion. The release of histamine precedes that of 
      acid secretion. The delay time and time of peak acid secretion occur later than 
      during histamine stimulation. Short exposure (pulse) results in transient 
      increases in both acid secretion and histamine release rates, while longer 
      exposure (step) results in prolonged increases in both variables. Dose-response 
      curves for pentagastrin pulses show that both the total amount of histamine 
      released and the total amount of acid secreted are saturable processes, 
      paralleling each other. Thus, the total amount of acid secreted is a function of 
      histamine (released) exposure (M min-1) in the extracellular space. Repeated 
      exposure will give multiple responses only if the time elapsed between the 
      stimuli is long enough. The magnitude of the responses depends on the length of 
      time intervals between the stimuli and the concentration of the stimuli. 
      Simultaneously administered pulses of histamine and pentagastrin result in merely 
      additive amount of acid being secreted. From these observations I conclude that 
      pentagastrin-induced acid secretion can be understood solely in terms of its 
      effect on histamine release and that depletion of histamine stores is responsible 
      for the observed refractoriness.
FAU - Ekblad, E B
AU  - Ekblad EB
LA  - eng
GR  - AM-21448/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
RN  - 820484N8I3 (Histamine)
RN  - EF0NX91490 (Pentagastrin)
SB  - IM
MH  - Animals
MH  - Extracellular Space/drug effects
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/drug effects
MH  - Histamine/pharmacology
MH  - Histamine Release/*drug effects
MH  - In Vitro Techniques
MH  - Pentagastrin/*pharmacology
MH  - Rana catesbeiana
MH  - Time Factors
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1111/j.1748-1716.1985.tb07700.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1985 Sep;125(1):135-43. doi: 
      10.1111/j.1748-1716.1985.tb07700.x.