PMID- 24137253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 6
IP  - 3
DP  - 2013 Sep
TI  - Correlation between gastrointestinal hormones and anxiety-depressive states in 
      irritable bowel syndrome.
PG  - 715-720
AB  - The aim of this study was to investigate the mechanism(s) of action of 
      gastrointestinal hormones in the pathogenesis of irritable bowel syndrome (IBS), 
      and the correlation between gastrointestinal hormones and psychological factors. 
      Patients with IBS were divided into IBS with normal emotional state ratings and 
      IBS in anxiety-depressive states groups. The two groups were then subdivided into 
      IBS-constipation predominant (IBS-C) and IBS-diarrhea predominant (IBS-D) groups. 
      Non-IBS patients with normal depression and anxiety ratings were recruited as 
      controls. The serum concentrations of somatostatin (SS) and vasoactive intestinal 
      peptide (VIP) were measured by radioimmunoassay, and the expression of SS and VIP 
      in the colonic mucosa was detected by immunohistochemistry and radioimmunoassay. 
      The anxiety-depression scores of patients with IBS were significantly different 
      from those of the control group (P<0.05). The expression levels of SS and VIP in 
      the serum and colonic mucosa of the patients with IBS were higher compared with 
      those of the control group. Furthermore, the expression level of SS in the IBS-C 
      group demonstrated a significantly larger increase than that in the IBS-D group 
      (P<0.05); however, there was no significant difference in the expression of VIP 
      between the IBS-C and IBS-D groups (P>0.05). In addition, the expression levels 
      of SS and VIP in the IBS groups with normal emotional state ratings were notably 
      different from those in the IBS groups in anxiety-depressive states (P<0.05). 
      Anxiety-depressive states may lead to changes in the secretion of SS and VIP, and 
      subsequently to changes in gastrointestinal motility and function.
FAU - Han, Baojuan
AU  - Han B
AD  - Department of Gastroenterology, Xingtai People's Hospital, Xingtai, Hebei 054031, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20130709
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3786850
OTO - NOTNLM
OT  - anxiety-depression
OT  - gastrointestinal hormones
OT  - irritable bowel syndrome
OT  - somatostatin
OT  - vasoactive intestinal peptide
EDAT- 2013/10/19 06:00
MHDA- 2013/10/19 06:01
PMCR- 2013/07/09
CRDT- 2013/10/19 06:00
PHST- 2013/03/06 00:00 [received]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/10/19 06:00 [entrez]
PHST- 2013/10/19 06:00 [pubmed]
PHST- 2013/10/19 06:01 [medline]
PHST- 2013/07/09 00:00 [pmc-release]
AID - etm-06-03-0715 [pii]
AID - 10.3892/etm.2013.1211 [doi]
PST - ppublish
SO  - Exp Ther Med. 2013 Sep;6(3):715-720. doi: 10.3892/etm.2013.1211. Epub 2013 Jul 9.