PMID- 24137947
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20131021
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 85
IP  - 7
DP  - 2013
TI  - [Eight-year experience in treating aggressive mediastinal large B-cell 
      lymphomas].
PG  - 50-6
AB  - AIM: To make a differential diagnosis of diffuse large B-cell lymphoma (DLBCL) 
      with primary involvement of the mediastinal lymph nodes (LN) and primary 
      mediastinal large B-cell lymphoma (PMLBCL); to evaluate the efficiency of a 
      modified NHL-BFM-90 (M-NHL-BFM-90) program in the treatment of the above 
      nosological entities. SUBJECTS AND METHODS: The investigation enrolled 60 
      patients with large B-cell lymphoma (LBCL) with primary involvement of 
      mediastinal LN who had been treated at the Hematology Research Center, Ministry 
      of Health of Russia, in 2004 to 2012. The diagnosis of PMLBCL and DLBCL with 
      primary involvement of mediastinal LN was based on histological findings, the 
      phenotype of tumor cells, and molecular evidence. Treatment was performed 
      according to the M-NHL-BFM-90 program. Three pregnant women received predelivery 
      polychemotherapy (PCT) according to the VACOP-B protocol and continued to have a 
      DexaBEAM chemotherapy regimen 3-4 weeks postpartum. In case of a residual mass, 
      all the patients underwent consolidation radiotherapy to the mediastinal area in 
      a total focal dose of 36 Gy. RESULTS: The diagnosis of PMLBCL was established in 
      39 patients: 10 men and 29 women whose ages were 18 to 60 years (median age 30 
      years); DLBCL with primary involvement of mediastinal LN was verified in 21 
      patients: 8 men and 13 women whose age was 21 to 70 years (median age 30 years). 
      After m-NHL-BFM-90 treatment protocol, 5-year overall survival rates in the 
      patients with DLBCL with primary involvement of mediastinal LN and in those with 
      PMLBCL were 95+/-5 and 86+/-6% and 5-year event-free survival rates were 95+/-5 
      and 78+/-7%, respectively. All the pregnant women diagnosed with PMLBCL who had 
      received the VACOP-B --> delivery--> Dexa-BEAM PCT regimen during pregnancy 
      achieved remission. The follow-up periods were 30, 36, and 42 weeks. CONCLUSION: 
      The patients with new-onset LBCL and primary involvement of mediastinal LN are a 
      heterogeneous group that includes patients having two different diagnoses: PMLBCL 
      and DLBCL. The efficiency of high-dose PCT is different in the patients with 
      DLBCL with primary involvement of mediastinal LN and in those with PMLBCL (in 
      spite of their similar clinical features, similar epidemiological 
      characteristics, and the presence of the same unfavorable prognostic factors at 
      onset).
FAU - Mangasarova, Ia K
AU  - Mangasarova IaK
FAU - Magomedova, A U
AU  - Magomedova AU
FAU - Kravchenko, S K
AU  - Kravchenko SK
FAU - Shmakov, R G
AU  - Shmakov RG
FAU - Bariakh, E A
AU  - Bariakh EA
FAU - Vorob'ev, V I
AU  - Vorob'ev VI
FAU - Mar'in, D S
AU  - Mar'in DS
FAU - Skidan, N I
AU  - Skidan NI
FAU - Gemdzhian, E G
AU  - Gemdzhian EG
FAU - Misiurin, A V
AU  - Misiurin AV
FAU - Kremenetskaia, A M
AU  - Kremenetskaia AM
FAU - Vorob'ev, A I
AU  - Vorob'ev AI
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Diagnosis, Differential
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*drug therapy/mortality/pathology
MH  - Male
MH  - Mediastinal Neoplasms/*drug therapy/mortality/pathology
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*drug therapy/mortality/pathology
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2013/10/22 06:00
MHDA- 2013/11/05 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
PST - ppublish
SO  - Ter Arkh. 2013;85(7):50-6.