PMID- 24138564
OWN - NLM
STAT- MEDLINE
DCOM- 20140910
LR  - 20221207
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 12
IP  - 1
DP  - 2014 Feb
TI  - The presence of at least three alleles of the ADRB3 Trp64Arg (C/T) and UCP1 
      -3826A/G polymorphisms is associated with protection to overweight/obesity and 
      with higher high-density lipoprotein cholesterol levels in Caucasian-Brazilian 
      patients with type 2 diabetes.
PG  - 16-24
LID - 10.1089/met.2013.0077 [doi]
AB  - BACKGROUND: We investigated whether the -3826A/G polymorphism (rs1800592) of the 
      uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the 
      beta3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus 
      (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. 
      METHODS: Both polymorphisms were genotyped in 1015 T2DM patients and 561 
      nondiabetic subjects. The combined effect of both polymorphisms on T2DM and 
      metabolic syndrome-related parameters was analyzed according to a triallelic 
      inheritance pattern, by which at least three minor alleles from two loci are 
      necessary for trait manifestation. RESULTS: UCP1 -3826A/G and ADRB3 Trp64Arg 
      polymorphisms were not associated with T2DM (P>0.05). Patients carrying the ADRB3 
      64Arg allele had higher fasting plasma glucose and high-density lipoprotein 
      cholesterol (HDL-C) than patients with the Trp64Trp genotype (P=0.0001 and 
      P=0.015, respectively). The 64Arg allele was also associated with protection 
      against overweight/obesity (body mass index >/= 25 kg/m(2); odds ratio [OR]=0.598; 
      P=0.014). Interestingly, prevalence of overweight/obesity was lower among 
      carriers of at least three minor alleles of the -3826A/G and ADRB3 Trp64Arg 
      polymorphisms than among patients with fewer than three minor alleles (54.5% vs. 
      79.1%; OR=0.288; P=0.007, respectively). Subjects with at least three minor 
      alleles also had higher HDL-C levels (P=0.018). CONCLUSIONS: UCP1 -3826A/G and 
      ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of 
      overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) 
      Caucasian-Brazilian patients.
FAU - Brondani, Leticia A
AU  - Brondani LA
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre , Universidade Federal 
      do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil .
FAU - Duarte, Guilherme C K
AU  - Duarte GC
FAU - Canani, Luis H
AU  - Canani LH
FAU - Crispim, Daisy
AU  - Crispim D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20131018
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (ADRB3 protein, human)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Ion Channels)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Receptors, Adrenergic, beta-3)
RN  - 0 (UCP1 protein, human)
RN  - 0 (Uncoupling Protein 1)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Blood Glucose
MH  - Brazil
MH  - Cholesterol, HDL/*blood
MH  - Diabetes Mellitus, Type 2/blood/ethnology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Ion Channels/*genetics
MH  - Male
MH  - Metabolic Syndrome/blood/ethnology/genetics
MH  - Middle Aged
MH  - Mitochondrial Proteins/*genetics
MH  - Obesity/*genetics
MH  - Odds Ratio
MH  - Overweight/*genetics
MH  - Polymorphism, Genetic
MH  - Receptors, Adrenergic, beta-3/*genetics
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Uncoupling Protein 1
MH  - White People
EDAT- 2013/10/22 06:00
MHDA- 2014/09/11 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/09/11 06:00 [medline]
AID - 10.1089/met.2013.0077 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2014 Feb;12(1):16-24. doi: 10.1089/met.2013.0077. Epub 
      2013 Oct 18.