PMID- 24138725
OWN - NLM
STAT- MEDLINE
DCOM- 20140912
LR  - 20151119
IS  - 1365-2303 (Electronic)
IS  - 0956-5507 (Linking)
VI  - 25
IP  - 1
DP  - 2014 Feb
TI  - Fine needle biopsy with cytology in paediatrics: the importance of a 
      multidisciplinary approach and the role of ancillary techniques.
PG  - 6-20
LID - 10.1111/cyt.12110 [doi]
AB  - Fine needle biopsy (FNB) with cytology has long been regarded as an excellent 
      technique as the first choice for diagnosing adult tumours. Being an inexpensive 
      minimally invasive technique with high accuracy and diagnostic immediacy through 
      rapid on-site evaluation, it is also ideal for implementation in the paediatric 
      setting, particularly in developing countries. Furthermore, it allows 
      complementary and advanced procedures such as flow cytometry, polymerase chain 
      reaction (PCR) or fluorescence in situ hybridization (FISH), among others, which 
      enhances the diagnostic capacity of this technique and gives it a key role in 
      risk stratification and therapeutic decision-making for several tumours. The 
      advantages of FNB are optimized in the setting of a multidisciplinary team where 
      cytologist, clinician and radiologist play leading roles. Paediatric tumours are 
      rare and most ancillary techniques are cost-effective but complex to be 
      implemented in small centres with limited experience in paediatric pathology. 
      Therefore reference centres are essential, in order to establish teams with 
      extensive experience and expertise. Hence, any child with a suspected malignancy 
      should be directly referred to a paediatric oncology unit. Focusing on a 
      practical approach to the assessment of paediatric lymphadenopathies and 
      non-central nervous system solid tumours we review the effectiveness of FNB as 
      applied concurrently with ancillary techniques in a multidisciplinary approach to 
      the diagnosis, prognosis and therapeutic decisions of paediatric tumours and 
      tumour-like lesions.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Barroca, H
AU  - Barroca H
AD  - Servico de Anatomia Patologica, Servico de Pediatria, Centro Hospitalar de S. 
      Joao, Porto, Portugal.
FAU - Bom-Sucesso, M
AU  - Bom-Sucesso M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131021
PL  - England
TA  - Cytopathology
JT  - Cytopathology : official journal of the British Society for Clinical Cytology
JID - 9010345
RN  - 0 (Biomarkers, Tumor)
SB  - IM
CIN - Cytopathology. 2014 Feb;25(1):3-5. PMID: 24411016
MH  - Biomarkers, Tumor/metabolism
MH  - *Biopsy, Fine-Needle/methods
MH  - Child
MH  - Humans
MH  - Neoplasms/*diagnosis
OTO - NOTNLM
OT  - ancillary techniques
OT  - cytology
OT  - fine needle biopsy
OT  - multidisciplinary approach
OT  - paediatric tumours
OT  - rapid on-site evaluation
EDAT- 2013/10/22 06:00
MHDA- 2014/09/13 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/08/08 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/09/13 06:00 [medline]
AID - 10.1111/cyt.12110 [doi]
PST - ppublish
SO  - Cytopathology. 2014 Feb;25(1):6-20. doi: 10.1111/cyt.12110. Epub 2013 Oct 21.