PMID- 24138783
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20240318
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Print)
IS  - 1438-4639 (Linking)
VI  - 217
IP  - 4-5
DP  - 2014 Apr-May
TI  - Thyroid hormones are associated with exposure to persistent organic pollutants in 
      aging residents of upper Hudson River communities.
PG  - 473-82
LID - S1438-4639(13)00132-6 [pii]
LID - 10.1016/j.ijheh.2013.09.003 [doi]
AB  - The aim of this study was to evaluate the association between persistent organic 
      pollutants (POPs) and thyroid hormones in an aging population. Forty-eight women 
      and 66 men, aged 55-74 years and living in upper Hudson River communities 
      completed a questionnaire and provided blood specimens. Serum was analyzed for 
      thyrotropin (thyroid stimulating hormone, TSH), free (fT4) and total thyroxine 
      (T4), total triiodothyronine (T3), and for POPs. POPs included 39 polychlorinated 
      biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT) and 
      dichlorodiphenyldichloroethylene (DDE) determined by gas chromatography with 
      electron capture detection (GC-ECD), and nine polybrominated diphenyl ethers 
      (PBDEs) determined by high-resolution gas chromatography with high-resolution 
      mass spectrometry detection (HRGC-HRMS). Multivariable linear regression analysis 
      was used to evaluate associations between thyroid hormones and sums of POPs, 
      adjusted for covariates and stratified by sex. Effects were expressed as 
      differences in thyroid hormone levels associated with a doubling in the level of 
      exposure. Among women, DDT+DDE increased T4 by 0.34mug/dL (P=0.04) and T3 by 
      2.78ng/dL (P=0.05). Also in women, sums of PCBs in conjunction with PBDEs 
      elicited increases of 24.39-80.85ng/dL T3 (P<0.05), and sums of PCBs in 
      conjunction with DDT+DDE elicited increases of 0.18-0.31mug/dL T4 (P<0.05). For 
      men estrogenic PCBs were associated with a 19.82ng/dL T3 decrease (P=0.003), and 
      the sum of estrogenic PCBs in conjunction with DDT+DDE elicited an 18.02ng/dL T3 
      decrease (P=0.04). Given age-related declines in physiologic reserve, the 
      influence of POPs on thyroid hormones in aging populations may have clinical 
      implications and merits further investigation.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - Bloom, Michael S
AU  - Bloom MS
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, School of Public Health, Rensselaer, NY, USA; Department 
      of Epidemiology and Biostatistics, University at Albany, State University of New 
      York, School of Public Health, Rensselaer, NY, USA. Electronic address: 
      mbloom@albany.edu.
FAU - Jansing, Robert L
AU  - Jansing RL
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, School of Public Health, Rensselaer, NY, USA; Wadsworth 
      Center, New York State Department of Health Wadsworth Center, Albany, NY, USA.
FAU - Kannan, Kurunthachalam
AU  - Kannan K
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, School of Public Health, Rensselaer, NY, USA; Wadsworth 
      Center, New York State Department of Health Wadsworth Center, Albany, NY, USA.
FAU - Rej, Robert
AU  - Rej R
AD  - Wadsworth Center, New York State Department of Health Wadsworth Center, Albany, 
      NY, USA; Department of Biomedical Sciences, University at Albany, State 
      University of New York, School of Public Health, Rensselaer, NY, USA.
FAU - Fitzgerald, Edward F
AU  - Fitzgerald EF
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, School of Public Health, Rensselaer, NY, USA; Department 
      of Epidemiology and Biostatistics, University at Albany, State University of New 
      York, School of Public Health, Rensselaer, NY, USA.
LA  - eng
GR  - R15 AG033379/AG/NIA NIH HHS/United States
GR  - R24 HD044943/HD/NICHD NIH HHS/United States
GR  - R15/AG033379-01A1/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130925
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Environmental Exposure/analysis
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - New York
MH  - Polychlorinated Biphenyls/blood
MH  - Rivers
MH  - Thyroid Hormones/*blood
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
PMC - PMC3965653
MID - NIHMS532306
OTO - NOTNLM
OT  - Aging
OT  - Dichlorodiphenyldichloroethylene (DDE)
OT  - Persistent organic pollutants (POPs)
OT  - Polybrominated diphenyl ethers (PBDEs)
OT  - Polychlorinated biphenyls (PCBs)
OT  - Thyroid hormones
EDAT- 2013/10/22 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/04/01
CRDT- 2013/10/22 06:00
PHST- 2013/04/01 00:00 [received]
PHST- 2013/09/05 00:00 [revised]
PHST- 2013/09/16 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - S1438-4639(13)00132-6 [pii]
AID - 10.1016/j.ijheh.2013.09.003 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2014 Apr-May;217(4-5):473-82. doi: 
      10.1016/j.ijheh.2013.09.003. Epub 2013 Sep 25.