PMID- 24138845
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 13
DP  - 2013 Oct 20
TI  - Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus 
      dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression.
PG  - 272
LID - 10.1186/1472-6882-13-272 [doi]
AB  - BACKGROUND: In Cameroonian traditional medicine various extracts of Gladiolus 
      dalenii Van Geel (Iridaceae) have been used as a cure for various ailments that 
      include headaches, digestive problems, muscle and joint aches, and some central 
      nervous system disorders such as epilepsy, schizophrenia and mood disorders. 
      Owning to this background, the aim of the study was to investigate whether an 
      aqueous macerate of the bulb of Gladiolus dalenii has any antidepressant activity 
      focusing specifically on depression-like behaviours associated with epilepsy. 
      METHOD: We used the combined administration of atropine and pilocarpine to rats 
      as our animal model of epilepsy. The forced swim test and spontaneous locomotor 
      activity in the open field test were the two tools used to assess the presence of 
      depression-like behaviour in epileptic and control animals. The following 
      depression-related parameters were determined: plasma ACTH, plasma 
      corticosterone, adrenal gland weight and hippocampal levels of brain-derived 
      neurotrophic factor (BDNF). The effects of Gladiolus dalenii were compared to 
      that of fluoxetine. RESULTS: Our results showed that we had a valid animal model 
      of epilepsy-induced depression as all 3 measures of construct, predictive and 
      face validity were satisfied. The data indicated that Gladiolus dalenii 
      significantly reduced the immobility times in the forced swim test and the 
      locomotor activity as assessed in the open field. A similar pattern was observed 
      when the HPA axis parameters were analysed. Gladiolus dalenii significantly 
      reduced the levels of ACTH, corticosterone, but not the adrenal gland weight. 
      Gladiolus dalenii significantly increased the level of BDNF in the hippocampus. 
      In all parameters measured the effects of Gladiolus dalenii were significantly 
      greater than those of fluoxetine. CONCLUSION: The results show that Gladiolus 
      dalenii has antidepressant-like properties similar to those of fluoxetine in 
      epilepsy-associated depressive states. The antidepressant activity of Gladiolus 
      dalenii is likely to be mediated by restoring the activity of the HPA axis and 
      increasing the levels of BDNF in the hippocampus.
FAU - Ngoupaye, Gwladys Temkou
AU  - Ngoupaye GT
AD  - Discipline of Human Physiology, School of Laboratory Medicine and Medical 
      Sciences, University of KwaZulu-Natal, Durban, South Africa. 
      gtngoupaye@gmail.com.
FAU - Bum, Elisabeth Ngo
AU  - Bum EN
FAU - Daniels, Willie Mark Uren
AU  - Daniels WM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131020
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Corticosterone/blood
MH  - Depression/blood/*drug therapy/etiology/genetics
MH  - Epilepsy/*complications
MH  - Flowers/chemistry
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Hypothalamo-Hypophyseal System
MH  - Iridaceae/*chemistry
MH  - Male
MH  - Pituitary-Adrenal System/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
PMC - PMC3854025
EDAT- 2013/10/22 06:00
MHDA- 2014/11/13 06:00
PMCR- 2013/10/20
CRDT- 2013/10/22 06:00
PHST- 2013/04/17 00:00 [received]
PHST- 2013/10/09 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
PHST- 2013/10/20 00:00 [pmc-release]
AID - 1472-6882-13-272 [pii]
AID - 10.1186/1472-6882-13-272 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2013 Oct 20;13:272. doi: 10.1186/1472-6882-13-272.