PMID- 24139196 OWN - NLM STAT- MEDLINE DCOM- 20140729 LR - 20221207 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 151 IP - 1-3 DP - 2013 Dec TI - The Longitudinal Youth at Risk Study (LYRIKS)--an Asian UHR perspective. PG - 279-83 LID - S0920-9964(13)00524-0 [pii] LID - 10.1016/j.schres.2013.09.025 [doi] AB - Numerous studies have been published on the psychosis prodrome and have explored a wide array of its many aspects. However, the set of risk factors identified by these various efforts is not homogenous across studies. This could be due to unique population factors or relatively small sample sizes. Only few studies were conducted on Asian populations, whose socio-cultural characteristics differ - in some cases remarkably - from those in western populations. Singapore is a highly dense city-state in South-east Asia, with low rates of substance abuse. The Longitudinal Youth at Risk Study (LYRIKS) commenced in Singapore in 2008, designed to comprehensively assess a group of ultra high risk (UHR) individuals and identify clinical, social, neuropsychological and biological risk factors unique to the local population. 173 UHR individuals were recruited from this single-site study over 4 years. Here, we detail aspects of the study methodology and report on the baseline social and clinical characteristics of the sample population. 78% of the UHR sample suffered from a psychiatric disorder, with Major Depressive Disorder present in more than half of the sample. The mean Global Assessment of Functioning (GAF) score was 57.4, which indicated a moderate level of impairment. Although the recruited sample did not differ significantly by social and clinical characteristics when compared to previously published reports, the conversion rate to psychosis was 3.5% (n=6) at 6 months. Follow-up measures are currently underway to assess longitudinal incidence of psychosis and impact of risk factors on cognition, functioning and remission. CI - (c) 2013 Elsevier B.V. All rights reserved. FAU - Lee, Jimmy AU - Lee J AD - Research Division, Institute of Mental Health, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore. Electronic address: Jimmy_lee@imh.com.sg. FAU - Rekhi, Gurpreet AU - Rekhi G FAU - Mitter, Natasha AU - Mitter N FAU - Bong, Yioe Ling AU - Bong YL FAU - Kraus, Michael S AU - Kraus MS FAU - Lam, Max AU - Lam M FAU - Rapisarda, Attilio AU - Rapisarda A FAU - Lee, Tih-Shih AU - Lee TS FAU - Subramaniam, Mythily AU - Subramaniam M FAU - Chong, Siow Ann AU - Chong SA FAU - Keefe, Richard S E AU - Keefe RS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131015 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 RN - S88TT14065 (Oxygen) SB - IM MH - Adolescent MH - Adult MH - Asian People MH - Brain/blood supply MH - Cognition Disorders/diagnosis/*etiology/pathology MH - Female MH - Follow-Up Studies MH - Humans MH - Image Processing, Computer-Assisted MH - Longitudinal Studies MH - Male MH - Neuropsychological Tests MH - Observation MH - Oxygen/blood MH - Psychiatric Status Rating Scales MH - *Psychotic Disorders/complications/epidemiology/psychology MH - Risk Factors MH - Singapore MH - Young Adult OTO - NOTNLM OT - Biomarker OT - CAARMS OT - Neuropsychology OT - Prodrome OT - Ultra high risk EDAT- 2013/10/22 06:00 MHDA- 2014/07/30 06:00 CRDT- 2013/10/22 06:00 PHST- 2013/05/31 00:00 [received] PHST- 2013/09/13 00:00 [revised] PHST- 2013/09/27 00:00 [accepted] PHST- 2013/10/22 06:00 [entrez] PHST- 2013/10/22 06:00 [pubmed] PHST- 2014/07/30 06:00 [medline] AID - S0920-9964(13)00524-0 [pii] AID - 10.1016/j.schres.2013.09.025 [doi] PST - ppublish SO - Schizophr Res. 2013 Dec;151(1-3):279-83. doi: 10.1016/j.schres.2013.09.025. Epub 2013 Oct 15.