PMID- 24139798
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20220129
IS  - 2211-1247 (Electronic)
VI  - 5
IP  - 2
DP  - 2013 Oct 31
TI  - Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a 
      neuroendocrine tumor model.
PG  - 482-92
LID - S2211-1247(13)00522-6 [pii]
LID - 10.1016/j.celrep.2013.09.014 [doi]
AB  - The extracellular matrix molecule tenascin-C (TNC) is a major component of the 
      cancer-specific matrix, and high TNC expression is linked to poor prognosis in 
      several cancers. To provide a comprehensive understanding of TNC's functions in 
      cancer, we established an immune-competent transgenic mouse model of pancreatic 
      beta-cell carcinogenesis with varying levels of TNC expression and compared 
      stochastic neuroendocrine tumor formation in abundance or absence of TNC. We show 
      that TNC promotes tumor cell survival, the angiogenic switch, more and leaky 
      vessels, carcinoma progression, and lung micrometastasis. TNC downregulates 
      Dickkopf-1 (DKK1) promoter activity through the blocking of actin stress fiber 
      formation, activates Wnt signaling, and induces Wnt target genes in tumor and 
      endothelial cells. Our results implicate DKK1 downregulation as an important 
      mechanism underlying TNC-enhanced tumor progression through the provision of a 
      proangiogenic tumor microenvironment.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Saupe, Falk
AU  - Saupe F
AD  - Inserm U1109, MN3T Team, The Microenvironmental Niche in Tumorigenesis and 
      Targeted Therapy, 3 Avenue Moliere, 67200 Strasbourg, France; Universite de 
      Strasbourg, 67000 Strasbourg, France; LabEx Medalis, Universite de Strasbourg, 
      67000 Strasbourg, France; Federation de Medecine Translationnelle de Strasbourg 
      (FMTS), 67000 Strasbourg, France.
FAU - Schwenzer, Anja
AU  - Schwenzer A
FAU - Jia, Yundan
AU  - Jia Y
FAU - Gasser, Isabelle
AU  - Gasser I
FAU - Spenle, Caroline
AU  - Spenle C
FAU - Langlois, Benoit
AU  - Langlois B
FAU - Kammerer, Martial
AU  - Kammerer M
FAU - Lefebvre, Olivier
AU  - Lefebvre O
FAU - Hlushchuk, Ruslan
AU  - Hlushchuk R
FAU - Rupp, Tristan
AU  - Rupp T
FAU - Marko, Marija
AU  - Marko M
FAU - van der Heyden, Michael
AU  - van der Heyden M
FAU - Cremel, Gerard
AU  - Cremel G
FAU - Arnold, Christiane
AU  - Arnold C
FAU - Klein, Annick
AU  - Klein A
FAU - Simon-Assmann, Patricia
AU  - Simon-Assmann P
FAU - Djonov, Valentin
AU  - Djonov V
FAU - Neuville-Mechine, Agnes
AU  - Neuville-Mechine A
FAU - Esposito, Irene
AU  - Esposito I
FAU - Slotta-Huspenina, Julia
AU  - Slotta-Huspenina J
FAU - Janssen, Klaus-Peter
AU  - Janssen KP
FAU - de Wever, Olivier
AU  - de Wever O
FAU - Christofori, Gerhard
AU  - Christofori G
FAU - Hussenet, Thomas
AU  - Hussenet T
FAU - Orend, Gertraud
AU  - Orend G
LA  - eng
GR  - 06-0610/AICR_/Worldwide Cancer Research/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131017
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Dkk1 protein, mouse)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Tenascin)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Transformation, Neoplastic
MH  - Disease Models, Animal
MH  - *Down-Regulation
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neovascularization, Pathologic
MH  - Neuroendocrine Tumors/metabolism/pathology
MH  - Signal Transduction
MH  - Tenascin/deficiency/genetics/*metabolism
MH  - Wnt Proteins/antagonists & inhibitors/*metabolism
EDAT- 2013/10/22 06:00
MHDA- 2015/01/13 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/03/20 00:00 [received]
PHST- 2013/08/07 00:00 [revised]
PHST- 2013/09/10 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - S2211-1247(13)00522-6 [pii]
AID - 10.1016/j.celrep.2013.09.014 [doi]
PST - ppublish
SO  - Cell Rep. 2013 Oct 31;5(2):482-92. doi: 10.1016/j.celrep.2013.09.014. Epub 2013 
      Oct 17.