PMID- 24139907
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 102
IP  - 2
DP  - 2013 Nov
TI  - Tumor necrosis factor-alpha (TNF-alpha) -863C/A promoter polymorphism is associated with 
      type 2 diabetes in Tunisian population.
PG  - e24-8
LID - S0168-8227(13)00336-7 [pii]
LID - 10.1016/j.diabres.2013.09.015 [doi]
AB  - AIMS: Tumor necrosis factor alpha (TNFalpha) plays a key role in orchestrating the 
      complex events involved in inflammation and immunity. Accordingly, TNF alpha has been 
      implicated in a wide range of autoimmune and infectious diseases, but also in 
      conditions such as obesity and insulin resistance. The aim of the present study 
      was to investigate the association between the -863C/A polymorphism in the 
      promoter of the TNFalpha gene and type 2 diabetes in the Tunisian population. 
      METHODS: The polymorphism -863C/A in the TNFalpha gene was determined in 211 type 2 
      diabetes patients and 345 healthy controls using the Polymerase Chain 
      Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis. RESULTS: A 
      significant difference in genotype distribution and allele frequency was observed 
      between patients and controls. Patients with type 2 diabetes had significantly 
      higher frequency of the CA+AA genotypes compared to controls [35.5% vs. 22.3%; OR 
      (95%CI), 1.91 (1.31-2.8); p=0.001]. The type 2 diabetes patient group showed a 
      significant higher frequency of the A allele compared to the controls (0.19 vs. 
      0.11; p=0.001). After adjustment by a stepwise logistic regression method, 
      hypertension, dyslipidemia, and CA+AA genotype were found to be significantly 
      associated with T2D. CONCLUSION: The present study showed a significant and 
      independent association between the -863C/A polymorphism of the TNFalpha gene and 
      type 2 diabetes in the Tunisian population.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Kallel, Amani
AU  - Kallel A
AD  - University of Tunis El Manar, la Rabta Hospital, LR99ES11 "Biochimie Clinique", 
      1007 Tunis, Tunisia.
FAU - Ftouhi, Bochra
AU  - Ftouhi B
FAU - Jemaa, Zeineb
AU  - Jemaa Z
FAU - Mahjoubi, Imen
AU  - Mahjoubi I
FAU - Feki, Moncef
AU  - Feki M
FAU - Slimane, Hedia
AU  - Slimane H
FAU - Jemaa, Riadh
AU  - Jemaa R
FAU - Kaabachi, Naziha
AU  - Kaabachi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131001
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
MH  - Tunisia/epidemiology
OTO - NOTNLM
OT  - Single nucleotide polymorphism
OT  - TNFalpha
OT  - Type 2 diabetes
EDAT- 2013/10/22 06:00
MHDA- 2014/10/29 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/02/14 00:00 [received]
PHST- 2013/05/09 00:00 [revised]
PHST- 2013/09/22 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
AID - S0168-8227(13)00336-7 [pii]
AID - 10.1016/j.diabres.2013.09.015 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2013 Nov;102(2):e24-8. doi: 
      10.1016/j.diabres.2013.09.015. Epub 2013 Oct 1.