PMID- 24140795 OWN - NLM STAT- MEDLINE DCOM- 20140910 LR - 20131230 IS - 1873-4367 (Electronic) IS - 0927-7765 (Linking) VI - 113 DP - 2014 Jan 1 TI - Improvement of corrosion and biological properties of microarc oxidized coatings on Mg-Zn-Zr alloy by optimizing negative power density parameters. PG - 421-8 LID - S0927-7765(13)00612-7 [pii] LID - 10.1016/j.colsurfb.2013.09.044 [doi] AB - Corrosion and biological properties of microarc oxidized calcium phosphate (CaP) coatings on Mg-Zn-Zr alloy were improved by optimizing negative power density parameters. Scanning electron microscope (SEM) and X-ray diffractometer (XRD) were employed to characterize the coating morphology and phase composition. The in vitro cytotoxicity and systemic toxicity tests were carried out to evaluate the coating biocompatibility. The degradability and bioactivity of the coatings were determined by in vitro simulated body fluid (SBF) immersion test. The coating microstructure, thickness and growth rate can be influenced by negative power density through changing direction of ions movements, rate of ions exchanges and affecting formation of plasma. The CaP coatings reduced the substrate degradation rate. Calcium phosphates, such as hydroxyapatite (Ca10(PO4)6(OH)2, HA) and calcium pyrophosphate (Ca2P2O7, CPP), etc., were induced after 30 days SBF immersion, indicating that the coatings have bioactivity. The CaP coatings have no toxicity to cell and living mice, indicating that the coatings are safe to serve as implants. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Pan, Y K AU - Pan YK AD - Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Ji'nan, Shandong 250061, People's Republic of China; School of Materials Science and Engineering, Shandong University, Ji'nan, Shandong 250061, People's Republic of China. FAU - Chen, C Z AU - Chen CZ AD - Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Ji'nan, Shandong 250061, People's Republic of China; School of Materials Science and Engineering, Shandong University, Ji'nan, Shandong 250061, People's Republic of China. Electronic address: czchen@sdu.edu.cn. FAU - Wang, D G AU - Wang DG AD - Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Ji'nan, Shandong 250061, People's Republic of China; School of Materials Science and Engineering, Shandong University, Ji'nan, Shandong 250061, People's Republic of China. FAU - Zhao, T G AU - Zhao TG AD - Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Ji'nan, Shandong 250061, People's Republic of China; School of Materials Science and Engineering, Shandong University, Ji'nan, Shandong 250061, People's Republic of China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130927 PL - Netherlands TA - Colloids Surf B Biointerfaces JT - Colloids and surfaces. B, Biointerfaces JID - 9315133 RN - 0 (Alloys) RN - 0 (Calcium Phosphates) RN - 97Z1WI3NDX (calcium phosphate) RN - C6V6S92N3C (Zirconium) RN - I38ZP9992A (Magnesium) RN - J41CSQ7QDS (Zinc) SB - IM MH - Alloys/*chemistry MH - Calcium Phosphates/chemistry MH - Corrosion MH - Magnesium/*chemistry MH - Zinc/*chemistry MH - Zirconium/*chemistry OTO - NOTNLM OT - Bioactivity OT - Biocompatibility OT - Calcium phosphate coating OT - Degradability OT - Magnesium alloy EDAT- 2013/10/22 06:00 MHDA- 2014/09/11 06:00 CRDT- 2013/10/22 06:00 PHST- 2013/07/30 00:00 [received] PHST- 2013/09/17 00:00 [revised] PHST- 2013/09/19 00:00 [accepted] PHST- 2013/10/22 06:00 [entrez] PHST- 2013/10/22 06:00 [pubmed] PHST- 2014/09/11 06:00 [medline] AID - S0927-7765(13)00612-7 [pii] AID - 10.1016/j.colsurfb.2013.09.044 [doi] PST - ppublish SO - Colloids Surf B Biointerfaces. 2014 Jan 1;113:421-8. doi: 10.1016/j.colsurfb.2013.09.044. Epub 2013 Sep 27.