PMID- 24141369
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20211021
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 123
IP  - 1
DP  - 2014 Jan 2
TI  - Impact of allele-level HLA matching on outcomes after myeloablative single unit 
      umbilical cord blood transplantation for hematologic malignancy.
PG  - 133-40
LID - 10.1182/blood-2013-05-506253 [doi]
AB  - We studied the effect of allele-level matching at human leukocyte antigen 
      (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) 
      transplantations for hematologic malignancy. The primary end point was nonrelapse 
      mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and 
      -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 
      alleles. In a subset, allele-level HLA match was assigned using imputation; 
      concordance between HLA-match assignment and outcome correlation was confirmed 
      between the actual and imputed HLA-match groups. Compared with HLA-matched units, 
      neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 
      alleles. NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles 
      compared with HLA-matched units. The observed effects are independent of cell 
      dose and patient age. These data support allele-level HLA matching in the 
      selection of single UCB units.
FAU - Eapen, Mary
AU  - Eapen M
AD  - Center for International Blood and Marrow Transplant Research.
FAU - Klein, John P
AU  - Klein JP
FAU - Ruggeri, Annalisa
AU  - Ruggeri A
FAU - Spellman, Stephen
AU  - Spellman S
FAU - Lee, Stephanie J
AU  - Lee SJ
FAU - Anasetti, Claudio
AU  - Anasetti C
FAU - Arcese, William
AU  - Arcese W
FAU - Barker, Juliet N
AU  - Barker JN
FAU - Baxter-Lowe, Lee Ann
AU  - Baxter-Lowe LA
FAU - Brown, Maria
AU  - Brown M
FAU - Fernandez-Vina, Marcelo A
AU  - Fernandez-Vina MA
FAU - Freeman, John
AU  - Freeman J
FAU - He, Wensheng
AU  - He W
FAU - Iori, Anna Paola
AU  - Iori AP
FAU - Horowitz, Mary M
AU  - Horowitz MM
FAU - Locatelli, Franco
AU  - Locatelli F
FAU - Marino, Susana
AU  - Marino S
FAU - Maiers, Martin
AU  - Maiers M
FAU - Michel, Gerard
AU  - Michel G
FAU - Sanz, Guillermo F
AU  - Sanz GF
FAU - Gluckman, Eliane
AU  - Gluckman E
FAU - Rocha, Vanderson
AU  - Rocha V
CN  - Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, 
      and the European Group for Blood and Marrow Transplantation
LA  - eng
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131018
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Blood. 2014 Jan 2;123(1):8-9. PMID: 24385496
MH  - Adolescent
MH  - Alleles
MH  - Child
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Female
MH  - Graft vs Host Disease/immunology
MH  - HLA Antigens/*immunology
MH  - Hematologic Neoplasms/genetics/*immunology/therapy
MH  - Histocompatibility/immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Male
MH  - Neutrophils/cytology
MH  - Recurrence
MH  - Treatment Outcome
PMC - PMC3879902
EDAT- 2013/10/22 06:00
MHDA- 2014/02/25 06:00
PMCR- 2015/01/02
CRDT- 2013/10/22 06:00
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
PHST- 2015/01/02 00:00 [pmc-release]
AID - S0006-4971(20)36207-8 [pii]
AID - 2013/506253 [pii]
AID - 10.1182/blood-2013-05-506253 [doi]
PST - ppublish
SO  - Blood. 2014 Jan 2;123(1):133-40. doi: 10.1182/blood-2013-05-506253. Epub 2013 Oct 
      18.