PMID- 24141611
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 46
IP  - 10
DP  - 2013 Oct
TI  - The left lung is preferentially targeted during experimental 
      paracoccidioidomycosis in C57BL/6 mice.
PG  - 839-43
LID - S0100-879X2013001000839 [pii]
LID - 10.1590/1414-431X20133140 [doi]
AB  - Paracoccidioidomycosis (PCM) is a chronic systemic mycosis caused by the 
      inhalation of the thermally dimorphic fungus Paracoccidioides brasiliensis as 
      well as the recently described P. lutzii. Because the primary infection occurs in 
      the lungs, we investigated the differential involvement of the right and left 
      lungs in experimental P. brasiliensis infection. Lungs were collected from 
      C57BL/6 mice at 70 days after intravenous infection with 1x106 yeast cells of a 
      virulent strain of P. brasiliensis (Pb18). The left lung, which in mice is 
      smaller and has fewer lobes than the right lung, yielded increased fungal 
      recovery associated with a predominant interleukin-4 response and diminished 
      synthesis of interferon-gamma and nitric oxide compared with the right lung. Our data 
      indicate differential involvement of the right and left lungs during experimental 
      PCM. This knowledge emphasizes the need for an accurate, standardized protocol 
      for tissue collection during studies of experimental P. brasiliensis infection, 
      since experiments using the same lungs favor the collection of comparable data 
      among different mice.
FAU - Tristao, F S M
AU  - Tristao FS
AD  - Departamento de Bioquimica e Imunologia, Faculdade de Medicina de Ribeirao Preto, 
      Universidade de Sao Paulo, Ribeirao PretoSP, Brasil.
FAU - Rocha, F A
AU  - Rocha FA
FAU - Dias, F C
AU  - Dias FC
FAU - Rossi, M A
AU  - Rossi MA
FAU - Silva, J S
AU  - Silva JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131002
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Interferon-gamma/analysis
MH  - Interleukin-10/analysis
MH  - Interleukin-4/analysis
MH  - Lung/*microbiology
MH  - Lung Diseases, Fungal/*microbiology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Nitric Oxide/analysis
MH  - *Paracoccidioides
MH  - Paracoccidioidomycosis/*microbiology
MH  - Time Factors
PMC - PMC3854305
EDAT- 2013/10/22 06:00
MHDA- 2015/08/15 06:00
PMCR- 2013/10/02
CRDT- 2013/10/22 06:00
PHST- 2013/04/05 00:00 [received]
PHST- 2013/07/29 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
PHST- 2013/10/02 00:00 [pmc-release]
AID - S0100-879X2013001000839 [pii]
AID - 10.1590/1414-431X20133140 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2013 Oct;46(10):839-43. doi: 10.1590/1414-431X20133140. Epub 
      2013 Oct 2.