PMID- 24141959
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20220321
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Print)
IS  - 0074-0276 (Linking)
VI  - 109
IP  - 1
DP  - 2014 Feb
TI  - Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase 
      expression by dendritic cells and subsequently impacts lymphocyte proliferation.
PG  - 70-9
LID - S0074-02762013005030252 [pii]
LID - 10.1590/0074-0276130252 [doi]
AB  - Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and 
      stimulate effective immune responses by T cells, but can also act as negative 
      regulators of these responses and thus play important roles in immune regulation. 
      Pro-angiogenic vascular endothelial growth factor (VEGF) has been shown to cause 
      defective DC differentiation and maturation. Previous studies have demonstrated 
      that the addition of VEGF to DC cultures renders these cells weak stimulators of 
      Ag-specific T cells due to the inhibitory effects mediated by VEGF receptor 1 
      (VEGFR1) and/or VEGFR2 signalling. As the enzyme indoleamine 2,3-dioxygenase 
      (IDO) is recognised as an important negative regulator of immune responses, this 
      study aimed to investigate whether VEGF affects the expression of IDO by DCs and 
      whether VEGF-matured DCs acquire a suppressor phenotype. Our results are the 
      first to demonstrate that VEGF increases the expression and activity of IDO in 
      DCs, which has a suppressive effect on Ag-specific and mitogen-stimulated 
      lymphocyte proliferation. These mechanisms have broad implications for the study 
      of immunological responses and tolerance under conditions as diverse as cancer, 
      graft rejection and autoimmunity.
FAU - Marti, Luciana Cavalheiro
AU  - Marti LC
AD  - Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert 
      Einstein.
FAU - Pavon, Lorena
AU  - Pavon L
AD  - Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert 
      Einstein.
FAU - Severino, Patricia
AU  - Severino P
AD  - Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert 
      Einstein.
FAU - Sibov, Tatiana
AU  - Sibov T
AD  - Centro de Pesquisa Experimental, Instituto do Cerebro, Hospital Israelita Albert 
      Einstein, Sao PauloSP, Brasil.
FAU - Guilhen, Daiane
AU  - Guilhen D
AD  - Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert 
      Einstein.
FAU - Moreira-Filho, Carlos Alberto
AU  - Moreira-Filho CA
AD  - Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert 
      Einstein.
LA  - eng
PT  - Journal Article
DEP - 20131009
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Antigens, Surface)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Antigens, Surface/biosynthesis
MH  - Apoptosis
MH  - Cell Culture Techniques
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation/*physiology
MH  - Cells, Cultured
MH  - Dendritic Cells/*drug effects/metabolism/ultrastructure
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics/*metabolism
MH  - Leukocytes, Mononuclear/physiology
MH  - Lymphocytes/*physiology
MH  - Monocytes/cytology/ultrastructure
MH  - Necrosis
MH  - Real-Time Polymerase Chain Reaction
MH  - Signal Transduction/immunology
MH  - Vascular Endothelial Growth Factor A/*pharmacology
PMC - PMC4005532
EDAT- 2013/10/22 06:00
MHDA- 2015/02/11 06:00
PMCR- 2014/02/01
CRDT- 2013/10/22 06:00
PHST- 2012/12/05 00:00 [received]
PHST- 2013/06/21 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0074-02762013005030252 [pii]
AID - 10.1590/0074-0276130252 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 2014 Feb;109(1):70-9. doi: 10.1590/0074-0276130252. Epub 
      2013 Oct 9.