PMID- 24142087
OWN - NLM
STAT- MEDLINE
DCOM- 20140507
LR  - 20181218
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 35
IP  - 3
DP  - 2013 Jul-Sep
TI  - Ketamine alters behavior and decreases BDNF levels in the rat brain as a function 
      of time after drug administration.
PG  - 262-6
LID - S1516-44462013000300262 [pii]
LID - 10.1590/1516-4446-2012-0858 [doi]
AB  - OBJECTIVE: To evaluate behavioral changes and brain-derived neurotrophic factor 
      (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. 
      METHOD: Behavioral evaluation was undertaken at 1 and 6 hours after the last 
      injection. RESULTS: We observed hyperlocomotion 1 hour after the last injection 
      and a decrease in locomotion after 6 hours. Immobility time was decreased and 
      climbing time was increased 6 hours after the last injection. BDNF levels were 
      decreased in the prefrontal cortex and amygdala when rats were killed 6 hours 
      after the last injection, compared to the saline group and to rats killed 1 hour 
      after the last injection. BDNF levels in the striatum were decreased in rats 
      killed 6 hours after the last ketamine injection, and BDNF levels in the 
      hippocampus were decreased in the groups that were killed 1 and 6 hours after the 
      last injection. CONCLUSION: These results suggest that the effects of ketamine on 
      behavior and BDNF levels are related to the time at which they were evaluated 
      after administration of the drug.
FAU - Fraga, Daiane B
AU  - Fraga DB
AD  - National Science and Technology Institute for Translational Medicine, Laboratory 
      of Neuroscience, CriciumaSC, Brazil.
FAU - Reus, Gislaine Z
AU  - Reus GZ
FAU - Abelaira, Helena M
AU  - Abelaira HM
FAU - De Luca, Renata D
AU  - De Luca RD
FAU - Canever, Leila
AU  - Canever L
FAU - Pfaffenseller, Bianca
AU  - Pfaffenseller B
FAU - Colpo, Gabriela D
AU  - Colpo GD
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Quevedo, Joao
AU  - Quevedo J
FAU - Zugno, Alexandra I
AU  - Zugno AI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Anesthetics, Dissociative)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Amygdala/drug effects/metabolism
MH  - Anesthetics, Dissociative/*administration & dosage
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corpus Striatum/drug effects/metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/metabolism
MH  - Ketamine/*administration & dosage
MH  - Male
MH  - Motor Activity/drug effects
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Swimming
MH  - Time Factors
EDAT- 2013/10/22 06:00
MHDA- 2014/05/08 06:00
CRDT- 2013/10/22 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/05/08 06:00 [medline]
AID - S1516-44462013000300262 [pii]
AID - 10.1590/1516-4446-2012-0858 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2013 Jul-Sep;35(3):262-6. doi: 10.1590/1516-4446-2012-0858.