PMID- 24142413
OWN - NLM
STAT- MEDLINE
DCOM- 20140217
LR  - 20211021
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 305
IP  - 12
DP  - 2013 Dec
TI  - Reduced BDNF attenuates inflammation and angiogenesis to improve survival and 
      cardiac function following myocardial infarction in mice.
PG  - H1830-42
LID - 10.1152/ajpheart.00224.2013 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) increases in failing hearts, but BDNF 
      roles in cardiac remodeling following myocardial infarction (MI) are unclear. 
      Male BDNF(+/+) [wild-type (WT)] and BDNF(+/-) heterozygous (HET) mice at 6-9 mo 
      of age were subjected to MI and evaluated at days 1, 3, 5, 7, or 28 post-MI. At 
      day 28 post-MI, 76% of HET versus 40% of WT survived, whereas fractional 
      shortening improved and neovascularization levels were reduced in the HET (all, P 
      < 0.05). At day 1, post-MI, matrix metalloproteinase-9, and myeloperoxidase (MPO) 
      increased in WT, but not in HET. Concomitantly, monocyte chemotactic protein-1 
      and -5 levels increased and vascular endothelial growth factor (VEGF)-A decreased 
      in HET. Neutrophil infiltration peaked at days 1-3 in WT mice, and this increase 
      was blunted in HET. To determine if MPO administration could rescue the HET 
      phenotype, MPO was injected at 3 h post-MI. MPO restored VEGF-A levels without 
      altering matrix metalloproteinase-9 or neutrophil content. In conclusion, reduced 
      BDNF levels modulated the early inflammatory and neovascularization responses, 
      leading to improved survival and reduced cardiac remodeling at day 28 post-MI. 
      Thus reduced BDNF attenuates early inflammation following MI by modulating MPO 
      and angiogenic response through VEGF-A.
FAU - Halade, Ganesh V
AU  - Halade GV
AD  - San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
FAU - Ma, Yonggang
AU  - Ma Y
FAU - Ramirez, Trevi A
AU  - Ramirez TA
FAU - Zhang, Jianhua
AU  - Zhang J
FAU - Dai, Qiuxia
AU  - Dai Q
FAU - Hensler, Julie G
AU  - Hensler JG
FAU - Lopez, Elizabeth F
AU  - Lopez EF
FAU - Ghasemi, Omid
AU  - Ghasemi O
FAU - Jin, Yu-Fang
AU  - Jin YF
FAU - Lindsey, Merry L
AU  - Lindsey ML
LA  - eng
GR  - R01-HL-075360/HL/NHLBI NIH HHS/United States
GR  - EB009496/EB/NIBIB NIH HHS/United States
GR  - R01 HL075360/HL/NHLBI NIH HHS/United States
GR  - R00 AT006704/AT/NCCIH NIH HHS/United States
GR  - N01-HV-00244/HV/NHLBI NIH HHS/United States
GR  - 1SC2 HL101430/HL/NHLBI NIH HHS/United States
GR  - I01 BX000505/BX/BLRD VA/United States
GR  - R00AT006704/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20131018
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Heart/drug effects/*physiopathology
MH  - Heterozygote
MH  - Inflammation/genetics/*metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Myocardial Infarction/genetics/*metabolism/physiopathology
MH  - Myocardium/*metabolism
MH  - Neovascularization, Pathologic/genetics/*metabolism
MH  - Neutrophils/drug effects/metabolism
MH  - Peroxidase/metabolism/pharmacology
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC3882541
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - inflammation
OT  - myeloperoxidase
OT  - myocardial infarction
OT  - obesity
OT  - proteomic profiling
EDAT- 2013/10/22 06:00
MHDA- 2014/02/18 06:00
PMCR- 2014/12/15
CRDT- 2013/10/22 06:00
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2014/02/18 06:00 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
AID - ajpheart.00224.2013 [pii]
AID - H-00224-2013 [pii]
AID - 10.1152/ajpheart.00224.2013 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1830-42. doi: 
      10.1152/ajpheart.00224.2013. Epub 2013 Oct 18.