PMID- 24142679
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20220330
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 21
IP  - 4
DP  - 2014
TI  - Association between time to reperfusion and echocardiography assessed left 
      ventricular filling pressure in patients with first ST-segment elevation 
      myocardial infarction undergoing primary coronary intervention.
PG  - 357-63
LID - 10.5603/CJ.a2013.0129 [doi]
AB  - BACKGROUND: Diastolic dysfunction and elevated left ventricular (LV) filling 
      pressure following acute myocardial infarction are associated with adverse 
      outcomes. Although time to reperfusion is a powerful prognostic marker following 
      acute myocardial infarction, little is known about its impact on diastolic 
      function and LV filling pressure. We hypothesized that delayed time to 
      reperfusion will be associated with worse diastolic function. METHODS: This study 
      included 180 consecutive patients with first ST elevation myocardial infarction 
      (STEMI) treated by primary percutaneous coronary intervention (PCI). They 
      presented of chest pain within 24 h and underwent echocardiography within 3 days 
      of primary PCI. RESULTS: Median time to reperfusion, defined as the time from 
      symptom onset to reperfusion at the end of primary PCI, was 185 min 
      (interquartile range 120-660). Patients with reperfusion time > 185 min (n = 92) 
      had a significantly higher E/septal e' (13.3 +/- 5.0 vs. 9.7 +/- 2.3, p < 0.001) and 
      E/lateral e' (9.8 +/- 3.5 vs. 7.8 +/- 2.2, p < 0.001) ratios, and more advanced 
      diastolic grade (p < 0.001) compared to those having early reperfusion (n = 88). 
      There were no significant differences in LV ejection fraction and left atrial 
      volume between the two groups. Time to reperfusion was an independent predictor 
      of early E/average e' ratio. The adverse effect of late reperfusion on diastolic 
      dysfunction was more prominent in patients with anterior myocardial infarction. 
      CONCLUSIONS: Longer time to reperfusion is associated with early elevated LV 
      diastolic pressure in primary PCI-treated patients with STEMI.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 
      kobyshacham@gmail.com.
FAU - Steinvil, Arie
AU  - Steinvil A
FAU - Leshem-Rubinow, Eran
AU  - Leshem-Rubinow E
FAU - Ben Assa, Eyal
AU  - Ben Assa E
FAU - Keren, Gad
AU  - Keren G
FAU - Roth, Arie
AU  - Roth A
FAU - Topilsky, Yan
AU  - Topilsky Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131021
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diastole
MH  - *Echocardiography, Doppler
MH  - Echocardiography, Doppler, Color
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/diagnostic imaging/physiopathology/*therapy
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - *Stroke Volume
MH  - Time Factors
MH  - *Time-to-Treatment
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/physiopathology
MH  - *Ventricular Function, Left
MH  - *Ventricular Pressure
EDAT- 2013/10/22 06:00
MHDA- 2016/04/20 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2013/08/28 00:00 [accepted]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - VM/OJS/J/35337 [pii]
AID - 10.5603/CJ.a2013.0129 [doi]
PST - ppublish
SO  - Cardiol J. 2014;21(4):357-63. doi: 10.5603/CJ.a2013.0129. Epub 2013 Oct 21.