PMID- 24142748
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20171116
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 72
IP  - 3
DP  - 2014
TI  - Apelin in ST segment elevation and non-ST segment elevation acute coronary 
      syndromes: a novel finding.
PG  - 239-45
LID - 10.5603/KP.a2013.0251 [doi]
AB  - BACKGROUND: Apelin is a novel endogenous peptide with inotropic and vasodilatory 
      properties. AIM: To investigate the role of apelin in the prognosis of acute 
      coronary syndromes (ACS) and to assess the relationship between apelin and other 
      diagnostic and prognostic markers. METHODS: Seventy-six patients with ACS (mean 
      age 62.1 +/- 10 years) were evaluated in terms of their plasma apelin-36 
      concentrations, ejection fraction (EF), high sensitivity C-reactive protein 
      (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group 
      consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST 
      elevation (NSTE) ACS patients. Patients were followed up for one year for 
      cardiovascular outcomes. RESULTS: There was no significant relationship between 
      apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups 
      (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in 
      patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 
      0.05). There were no statistically significant differences between patients 
      reaching the composite end point at one year with regard to apelin levels. 
      CONCLUSIONS: Apelin was positively correlated with cardiac biomarkers in patients 
      with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, 
      generally larger amounts of myocardial cells are subjected to infarction compared 
      to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, 
      CK-MB and troponin levels in STEMI patients.
FAU - Cosansu, Kahraman
AU  - Cosansu K
FAU - Cakmak, Huseyin Altug
AU  - Cakmak HA
FAU - Ikitimur, Baris
AU  - Ikitimur B
FAU - Yildirim, Erkan
AU  - Yildirim E
FAU - Can, Gunay
AU  - Can G
AD  - Istanbul University, Cerrahpasa Medical Faculty, Department of Public Health. 
      alpincan@yahoo.fr.
FAU - Karadag, Bilgehan
AU  - Karadag B
FAU - Koldas, Lale
AU  - Koldas L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131021
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (APLN protein, human)
RN  - 0 (Apelin)
RN  - 0 (Biomarkers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Aged
MH  - Apelin
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Creatine Kinase/blood
MH  - Creatine Kinase, MB Form/blood
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/physiopathology
MH  - Prognosis
EDAT- 2013/10/22 06:00
MHDA- 2016/12/15 06:00
CRDT- 2013/10/22 06:00
PHST- 2013/03/30 00:00 [received]
PHST- 2013/09/09 00:00 [accepted]
PHST- 2013/07/24 00:00 [revised]
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - VM/OJS/KP/7753 [pii]
AID - 10.5603/KP.a2013.0251 [doi]
PST - ppublish
SO  - Kardiol Pol. 2014;72(3):239-45. doi: 10.5603/KP.a2013.0251. Epub 2013 Oct 21.