PMID- 24143106
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 9
DP  - 2013
TI  - Evidence for single nucleotide polymorphisms and their association with bipolar 
      disorder.
PG  - 1573-82
LID - 10.2147/NDT.S28117 [doi]
AB  - Bipolar disorder (BD) is a complex disorder with a number of susceptibility genes 
      and environmental risk factors involved in its pathogenesis. In recent years, 
      huge progress has been made in molecular techniques for genetic studies, which 
      have enabled identification of numerous genomic regions and genetic variants 
      implicated in BD across populations. Despite the abundance of genetic findings, 
      the results have often been inconsistent and not replicated for many candidate 
      genes/single nucleotide polymorphisms (SNPs). Therefore, the aim of the review 
      presented here is to summarize the most important data reported so far in 
      candidate gene and genome-wide association studies. Taking into account the 
      abundance of association data, this review focuses on the most extensively 
      studied genes and polymorphisms reported so far for BD to present the most 
      promising genomic regions/SNPs involved in BD. The review of association data 
      reveals evidence for several genes (SLC6A4/5-HTT [serotonin transporter gene], 
      BDNF [brain-derived neurotrophic factor], DAOA [D-amino acid oxidase activator], 
      DTNBP1 [dysbindin], NRG1 [neuregulin 1], DISC1 [disrupted in schizophrenia 1]) to 
      be crucial candidates in BD, whereas numerous genome-wide association studies 
      conducted in BD indicate polymorphisms in two genes (CACNA1C [calcium channel, 
      voltage-dependent, L type, alpha 1C subunit], ANK3 [ankyrin 3]) replicated for 
      association with BD in most of these studies. Nevertheless, further studies 
      focusing on interactions between multiple candidate genes/SNPs, as well as 
      systems biology and pathway analyses are necessary to integrate and improve the 
      way we analyze the currently available association data.
FAU - Szczepankiewicz, Aleksandra
AU  - Szczepankiewicz A
AD  - Laboratory of Molecular and Cell Biology, Poznan University of Medical Sciences, 
      Poznan, Poland ; Department of Psychiatric Genetics, Poznan University of Medical 
      Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131011
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC3798233
OTO - NOTNLM
OT  - BDNF
OT  - DAOA
OT  - DISC1
OT  - DTNBP1
OT  - NRG1
OT  - SLC6A4
OT  - candidate gene
OT  - genome-wide association study
EDAT- 2013/10/22 06:00
MHDA- 2013/10/22 06:01
PMCR- 2013/10/11
CRDT- 2013/10/22 06:00
PHST- 2013/10/22 06:00 [entrez]
PHST- 2013/10/22 06:00 [pubmed]
PHST- 2013/10/22 06:01 [medline]
PHST- 2013/10/11 00:00 [pmc-release]
AID - ndt-9-1573 [pii]
AID - 10.2147/NDT.S28117 [doi]
PST - ppublish
SO  - Neuropsychiatr Dis Treat. 2013;9:1573-82. doi: 10.2147/NDT.S28117. Epub 2013 Oct 
      11.