PMID- 24144510
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 221
IP  - 1
DP  - 2014 Jan 30
TI  - Altered relationships between age and functional brain activation in adolescents 
      at clinical high risk for psychosis.
PG  - 21-9
LID - S0925-4927(13)00217-5 [pii]
LID - 10.1016/j.pscychresns.2013.08.004 [doi]
AB  - Schizophrenia is considered a neurodevelopmental disorder, but whether the 
      adolescent period, proximal to onset, is associated with aberrant development in 
      individuals at clinical high risk (CHR) for psychosis is incompletely understood. 
      While abnormal gray and white matter development has been observed, alterations 
      in functional neuroimaging (fMRI) parameters during adolescence as related to 
      conversion to psychosis have not yet been investigated. Twenty CHR individuals 
      and 19 typically developing controls (TDC), (ages 14-21), were recruited from the 
      Center for Assessment and Prevention of Prodromal States (CAPPS) at UCLA. 
      Participants performed a Sternberg-style verbal working memory (WMem) task during 
      fMRI and data were analyzed using a cross-sectional design to test the hypothesis 
      that there is a deviant developmental trajectory in WMem associated neural 
      circuitry in those at risk for psychosis. Eight of the CHR adolescents converted 
      to psychosis within 2 years of initial assessment. A voxel-wise regression 
      examining the relationship between age and activation revealed a significant 
      group-by-age interaction. TDC showed a negative association between age and 
      functional activation in the WMem circuitry while CHR adolescents showed a 
      positive association. Moreover, CHR patients who later converted to overt 
      psychosis showed a distinct pattern of abnormal age-associated activation in the 
      frontal cortex relative to controls, while non-converters showed a more diffuse 
      posterior pattern. Finding that age related variation in baseline patterns of 
      neural activity differentiate individuals who subsequently convert to psychosis 
      from healthy subjects suggests that these differences are likely to be clinically 
      relevant.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Karlsgodt, Katherine H
AU  - Karlsgodt KH
AD  - Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY 11004, USA; 
      Feinstein Institute for Medical Research, Manhasset, NY, USA. Electronic address: 
      kkarlsgodt@nshs.edu.
FAU - van Erp, Theo G M
AU  - van Erp TG
AD  - Departments of Psychiatry and Human Behavior, University of California Irvine, 
      Irvine, CA, USA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Departments of Psychiatry and Psychology, University of California, Los Angeles, 
      CA, USA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Departments of Psychology and Psychiatry, Yale University, New Haven, CT, USA.
LA  - eng
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - U54 EB020403/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20131019
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Brain/*blood supply/pathology/physiopathology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Frontal Lobe/blood supply/pathology/physiopathology
MH  - Functional Neuroimaging
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Memory, Short-Term
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/etiology/*pathology
MH  - Recognition, Psychology
MH  - Risk Factors
MH  - Schizophrenia/complications/physiopathology
MH  - Verbal Learning/physiology
MH  - Young Adult
PMC - PMC3921908
MID - NIHMS533723
OTO - NOTNLM
OT  - Development
OT  - Prodrome
OT  - Psychosis
OT  - Schizophrenia
OT  - Working memory
OT  - fMRI
EDAT- 2013/10/23 06:00
MHDA- 2014/11/06 06:00
PMCR- 2015/01/30
CRDT- 2013/10/23 06:00
PHST- 2012/12/31 00:00 [received]
PHST- 2013/08/08 00:00 [revised]
PHST- 2013/08/09 00:00 [accepted]
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
PHST- 2015/01/30 00:00 [pmc-release]
AID - S0925-4927(13)00217-5 [pii]
AID - 10.1016/j.pscychresns.2013.08.004 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Jan 30;221(1):21-9. doi: 10.1016/j.pscychresns.2013.08.004. 
      Epub 2013 Oct 19.