PMID- 24145095
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20200106
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 65
IP  - 4
DP  - 2013
TI  - Dose-depending effect of intracerebroventricularly administered bradykinin on 
      nociception in rats.
PG  - 1006-11
AB  - BACKGROUND: The effect of small and high doses of intracerebroventricularly (icv) 
      applied bradykinin (BK) on nociception produced by mechanical stimuli and the 
      participation of B1 and B2 receptors in this nociception were investigated in 
      rats. RESULTS: BK at the lowest dose (0.06 mug) produced hyperalgesia whereas at 
      the higher doses (6 and 12 mug) antinociception. This effect was abolished by B1 
      or B2 receptor antagonists, des-Arg(10)-HOE140 and HOE140 (1 pmol icv), 
      respectively. CONCLUSION: Depending on the dose used, BK produces pro- or 
      anti-nociceptive action. Both B1 and B2 receptors are involved in the action of 
      icv applied BK.
FAU - Bujalska-Zadrozny, Magdalena
AU  - Bujalska-Zadrozny M
AD  - Department of Pharmacodynamics, Medical University of Warsaw, Krakowskie 
      Przedmiescie 26/28, PL 00-927 Warszawa 64, P.O. Box 3, Poland. 
      mbujalska@gmail.com.
FAU - de Corde, Anna
AU  - de Corde A
FAU - Cegielska-Perun, Krystyna
AU  - Cegielska-Perun K
FAU - Gasinska, Emilia
AU  - Gasinska E
FAU - Makulska-Nowak, Helena
AU  - Makulska-Nowak H
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Bradykinin B1 Receptor Antagonists)
RN  - 0 (Bradykinin B2 Receptor Antagonists)
RN  - 0 (Receptor, Bradykinin B1)
RN  - 0 (Receptor, Bradykinin B2)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 138680-92-9 (HOE 140, desArg(10)-)
RN  - 7PG89G35Q7 (icatibant)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Animals
MH  - Bradykinin/administration & dosage/analogs & derivatives/antagonists & 
      inhibitors/*pharmacology
MH  - Bradykinin B1 Receptor Antagonists
MH  - Bradykinin B2 Receptor Antagonists
MH  - Dose-Response Relationship, Drug
MH  - Hyperalgesia/chemically induced
MH  - Infusions, Intraventricular
MH  - Male
MH  - Nociception/*drug effects
MH  - Rats
MH  - Receptor, Bradykinin B1/agonists
MH  - Receptor, Bradykinin B2/agonists
MH  - Tetrahydroisoquinolines/pharmacology
EDAT- 2013/10/23 06:00
MHDA- 2014/06/15 06:00
CRDT- 2013/10/23 06:00
PHST- 2012/09/06 00:00 [received]
PHST- 2013/04/23 00:00 [revised]
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
AID - S1734-1140(13)71082-X [pii]
AID - 10.1016/s1734-1140(13)71082-x [doi]
PST - ppublish
SO  - Pharmacol Rep. 2013;65(4):1006-11. doi: 10.1016/s1734-1140(13)71082-x.