PMID- 24146091
OWN - NLM
STAT- MEDLINE
DCOM- 20140528
LR  - 20131024
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 8
IP  - 6
DP  - 2013 Dec
TI  - Altered expression of pannexin proteins in patients with temporal lobe epilepsy.
PG  - 1801-6
LID - 10.3892/mmr.2013.1739 [doi]
AB  - The aim of the present study was to investigate the expression of the pannexin 
      (Panx) proteins, Panx1 and Panx2, in the temporal lobe tissue of patients with 
      temporal lobe epilepsy (TLE). Immunohistochemistry and western blotting methods 
      were used to localize and quantify Panx1 and Panx2 in the surgically removed 
      brain tissue of patients with TLE (n=37). The results were then compared with 
      non-epileptogenic controls (n=9). Panx1 and Panx2 expression was detected in the 
      temporal lobe cortex of patients with TLE and in the control tissues. Panx1 and 
      Panx2 proteins were expressed in all layers of the epileptic cortex, but 
      predominantly in layers II and III of the cortex in the control group. Panx1 
      protein expression was significantly higher in the temporal lobe cortex of the 
      patients with TLE than in the controls (P<0.05; t-test); however, no significant 
      differences were identified in the Panx2 expression levels between the patients 
      and the controls (P>0.05; t-test). The expression of the two Panx proteins in the 
      tissue layers of the epileptic cortex varied in the patients and controls. The 
      results indicate that Panx channels may be involved in the pathogenesis of TLE.
FAU - Jiang, Ting
AU  - Jiang T
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Long, Hongyu
AU  - Long H
FAU - Ma, Yan
AU  - Ma Y
FAU - Long, Lili
AU  - Long L
FAU - Li, Yi
AU  - Li Y
FAU - Li, Feng
AU  - Li F
FAU - Zhou, Pinting
AU  - Zhou P
FAU - Yuan, Chunyun
AU  - Yuan C
FAU - Xiao, Bo
AU  - Xiao B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131018
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Connexins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PANX1 protein, human)
RN  - 0 (PANX2 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blotting, Western
MH  - Case-Control Studies
MH  - Cerebral Cortex/metabolism/pathology
MH  - Child
MH  - Child, Preschool
MH  - Connexins/*metabolism
MH  - Epilepsy, Temporal Lobe/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Nerve Tissue Proteins/*metabolism
MH  - Young Adult
EDAT- 2013/10/23 06:00
MHDA- 2014/05/29 06:00
CRDT- 2013/10/23 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2013/10/07 00:00 [accepted]
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/05/29 06:00 [medline]
AID - 10.3892/mmr.2013.1739 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Dec;8(6):1801-6. doi: 10.3892/mmr.2013.1739. Epub 2013 Oct 18.