PMID- 24146271
OWN - NLM
STAT- MEDLINE
DCOM- 20140612
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 251
IP  - 12
DP  - 2013 Dec
TI  - Spectral-domain optical coherence tomography analysis in deprivational amblyopia: 
      a pilot study with unilateral pediatric cataract patients.
PG  - 2811-9
LID - 10.1007/s00417-013-2494-1 [doi]
AB  - BACKGROUND: To investigate whether macular and peripapillary retinal nerve fiber 
      layer (RNFL) structure differs among deprivational amblyopic eyes, fellow 
      non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical 
      coherence tomography (SD-OCT). METHODS: Macula and optic disc of 14 unilateral 
      pseudophakic children with deprivational amblyopia, and 14 age-matched normal 
      children (mean age, 7.45 +/- 2.57 years) were scanned with Cirrus(TM) HD-OCT. 
      Macular, RNFL, and macular ganglion cell-inner plexiform layer (GCIPL) 
      thicknesses were measured, and compared between the eyes after correction for 
      axial length-related magnification errors. RESULTS: The average RNFL thickness 
      tended to be greater in amblyopic eyes (99.64 +/- 10.11 mum) than in fellow 
      non-amblyopic eyes (97.28 +/- 12.34 mum) and normal eyes (95.38 +/- 9.74 mum), but did 
      not show statistical significance (p = 0.429, p = 0.286 respectively). The nasal 
      RNFL thickness was significantly greater in amblyopic eyes (75.84 +/- 19.22 mum) 
      than in fellow non-amblyopic eyes (63.42 +/- 14.05 mum, p = 0.037) and normal eyes 
      (62.38 +/- 9.65 mum, p = 0.043). The central macular thickness in amblyopic eyes 
      (237.05 +/- 37.74 mum) showed no significant differences compared to those of fellow 
      non-amblyopic eyes (226.67 +/- 34.71 mum) and normal eyes (233.74 +/- 27.11 mum) (p = 
      0.137, p = 0.792 respectively). The macular GCIPL thickness showed no significant 
      difference among the amblyopic, fellow non-amblyopic, and normal eyes (average; 
      78.94 +/- 6.35 mum vs 78.77 +/- 6.43 mum vs 82.22 +/- 5.00 mum respectively, p > 0.05). 
      CONCLUSIONS: SD-OCT analysis of deprivational amblyopic eyes with unilateral 
      pediatric cataract demonstrated significant increase in nasal RNFL thickness 
      compared to fellow non-amblyopic eyes and age-matched normal eyes. The macular 
      and macular GCIPL thickness did not show any significant difference. Taken 
      together, monocular pattern deprivation in early childhood may have changed the 
      nasal peripapillary RNFL structure.
FAU - Kim, Yong Woo
AU  - Kim YW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic 
      of Korea.
FAU - Kim, Seong-Joon
AU  - Kim SJ
FAU - Yu, Young Suk
AU  - Yu YS
LA  - eng
PT  - Journal Article
DEP - 20131022
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Amblyopia/*etiology
MH  - Cataract/*complications
MH  - Cataract Extraction
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lens Implantation, Intraocular
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Pilot Projects
MH  - Retinal Ganglion Cells/*pathology
MH  - *Sensory Deprivation
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2013/10/23 06:00
MHDA- 2014/06/13 06:00
CRDT- 2013/10/23 06:00
PHST- 2013/06/17 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/08/27 00:00 [revised]
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/06/13 06:00 [medline]
AID - 10.1007/s00417-013-2494-1 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2013 Dec;251(12):2811-9. doi: 
      10.1007/s00417-013-2494-1. Epub 2013 Oct 22.