PMID- 24146316
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20220716
IS  - 1531-135X (Electronic)
IS  - 1530-7026 (Linking)
VI  - 14
IP  - 2
DP  - 2014 Jun
TI  - Maternal supplementation of nucleotides improves the behavioral development of 
      prenatal ethanol-exposed mice.
PG  - 879-90
LID - 10.3758/s13415-013-0218-y [doi]
AB  - Maternal ethanol consumption during pregnancy can induce learning deficits in the 
      offspring. The objective of this study was to assess whether supplementation of 
      exogenous nucleotides during pregnancy and lactation would ameliorate prenatal 
      ethanol-induced learning and memory deficits in the offspring of mice, and to 
      explore the possible mechanisms. In the present study, pregnant C57BL/6J mice 
      were exposed to ethanol (5 g/kg body weight) intragastrically from gestational 
      day (GD) 6 to GD15. The dams in exogenous nucleotide intervention groups were fed 
      with feed containing 0.01%, 0.04%, or 0.16% nucleotide powder, with control and 
      ethanol groups receiving normal feed. The dams were allowed to deliver naturally 
      and to breast feed their offspring. After weaning, behavioral tests were carried 
      out in the offspring of each group. Serum oxidation indexes were analyzed, and 
      the hippocampus of each offspring was collected and detected for acetyl 
      cholinesterase (AChE) activity and the expression of p-CREB, CREB, and BDNF. The 
      results showed that maternal supplementation with exogenous nucleotides during 
      pregnancy could ameliorate prenatal ethanol-induced learning and memory deficits 
      in the offspring of mice, through improving their antioxidant capacity, reversing 
      hippocampus AChE levels, and allowing the expression of some proteins related to 
      learning and memory. However, different sensitivities were found between the two 
      sexes.
FAU - Dong, Wenhong
AU  - Dong W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, China.
FAU - Wu, Zhenghao
AU  - Wu Z
FAU - Xu, Linlin
AU  - Xu L
FAU - Fang, Yuehui
AU  - Fang Y
FAU - Xu, Yajun
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cogn Affect Behav Neurosci
JT  - Cognitive, affective & behavioral neuroscience
JID - 101083946
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nucleotides)
RN  - 3K9958V90M (Ethanol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight
MH  - Central Nervous System Depressants/blood/*toxicity
MH  - Developmental Disabilities/blood/*etiology/*prevention & control
MH  - Escape Reaction
MH  - Ethanol/blood/*toxicity
MH  - Exploratory Behavior
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Hippocampus/metabolism
MH  - Male
MH  - Malondialdehyde/blood
MH  - Maze Learning
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nucleotides/*administration & dosage
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/blood/physiopathology/*prevention & control
MH  - Superoxide Dismutase/blood
EDAT- 2013/10/23 06:00
MHDA- 2015/02/11 06:00
CRDT- 2013/10/23 06:00
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - 10.3758/s13415-013-0218-y [doi]
PST - ppublish
SO  - Cogn Affect Behav Neurosci. 2014 Jun;14(2):879-90. doi: 
      10.3758/s13415-013-0218-y.