PMID- 24146374 OWN - NLM STAT- MEDLINE DCOM- 20140509 LR - 20131022 IS - 0306-0225 (Print) IS - 0306-0225 (Linking) VI - 75 DP - 2014 TI - Structure and catalytic mechanism of beta-carbonic anhydrases. PG - 53-76 LID - 10.1007/978-94-007-7359-2_4 [doi] AB - The beta-carbonic anhydrases (beta-CAs) are a structurally distinct family of carbonic anhydrase that is widely distributed in microorganisms, algae, plants, and invertebrates. Like all carbonic anhydrases, beta-CAs catalyze the reaction CO2 + H2O left arrow over right arrow HCO3 (-) + H(+), and is typically associated with other enzymes that produce or utilize CO2 or HCO3 (-). beta-CA is required for normal growth for many organisms. Unique among the five different families of carbonic anhydrases, beta-CA is the only family of carbonic anhydrase to exhibit allostery. This chapter summarizes the structure, catalytic mechanism, and allosteric regulation of beta-CA. FAU - Rowlett, Roger S AU - Rowlett RS AD - Department of Chemistry, Colgate University, Hamilton, NY, USA, rrowlett@colgate.edu. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review PL - United States TA - Subcell Biochem JT - Sub-cellular biochemistry JID - 0316571 RN - 0 (Bicarbonates) RN - 0 (Protons) RN - EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase) RN - EC 4.2.1.1 (Carbonic Anhydrases) SB - IM MH - Allosteric Regulation MH - Arabidopsis MH - Bicarbonates/chemistry MH - Carbonic Anhydrases/*chemistry/metabolism MH - Catalysis MH - *Crystallography, X-Ray MH - *Protein Conformation MH - Protein Structure, Quaternary MH - Protons MH - Ribulose-Bisphosphate Carboxylase/*chemistry/metabolism EDAT- 2013/10/23 06:00 MHDA- 2014/05/10 06:00 CRDT- 2013/10/23 06:00 PHST- 2013/10/23 06:00 [entrez] PHST- 2013/10/23 06:00 [pubmed] PHST- 2014/05/10 06:00 [medline] AID - 10.1007/978-94-007-7359-2_4 [doi] PST - ppublish SO - Subcell Biochem. 2014;75:53-76. doi: 10.1007/978-94-007-7359-2_4.