PMID- 24146937
OWN - NLM
STAT- MEDLINE
DCOM- 20140814
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 10
DP  - 2013
TI  - Long-term potentiation promotes proliferation/survival and neuronal 
      differentiation of neural stem/progenitor cells.
PG  - e76860
LID - 10.1371/journal.pone.0076860 [doi]
LID - e76860
AB  - Neural stem cell (NSC) replacement therapy is considered a promising cell 
      replacement therapy for various neurodegenerative diseases. However, the low rate 
      of NSC survival and neurogenesis currently limits its clinical potential. Here, 
      we examined if hippocampal long-term potentiation (LTP), one of the most well 
      characterized forms of synaptic plasticity, promotes neurogenesis by facilitating 
      proliferation/survival and neuronal differentiation of NSCs. We found that the 
      induction of hippocampal LTP significantly facilitates proliferation/survival and 
      neuronal differentiation of both endogenous neural progenitor cells (NPCs) and 
      exogenously transplanted NSCs in the hippocampus in rats. These effects were 
      eliminated by preventing LTP induction by pharmacological blockade of the 
      N-methyl-D-aspartate glutamate receptor (NMDAR) via systemic application of the 
      receptor antagonist, 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid 
      (CPP). Moreover, using a NPC-neuron co-culture system, we were able to 
      demonstrate that the LTP-promoted NPC neurogenesis is at least in part mediated 
      by a LTP-increased neuronal release of brain-derived neurotrophic factor (BDNF) 
      and its consequent activation of tropomysosin receptor kinase B (TrkB) receptors 
      on NSCs. Our results indicate that LTP promotes the neurogenesis of both 
      endogenous and exogenously transplanted NSCs in the brain. The study suggests 
      that pre-conditioning of the host brain receiving area with a LTP-inducing deep 
      brain stimulation protocol prior to NSC transplantation may increase the 
      likelihood of success of using NSC transplantation as an effective cell therapy 
      for various neurodegenerative diseases.
FAU - Cho, Taesup
AU  - Cho T
AD  - Brain Research Centre and Department of Medicine, University of British Columbia, 
      Vancouver, Canada.
FAU - Ryu, Jae K
AU  - Ryu JK
FAU - Taghibiglou, Changiz
AU  - Taghibiglou C
FAU - Ge, Yuan
AU  - Ge Y
FAU - Chan, Allen W
AU  - Chan AW
FAU - Liu, Lidong
AU  - Liu L
FAU - Lu, Jie
AU  - Lu J
FAU - McLarnon, James G
AU  - McLarnon JG
FAU - Wang, Yu Tian
AU  - Wang YT
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131017
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - CA1 Region, Hippocampal/cytology/metabolism
MH  - *Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Separation
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Dentate Gyrus/cytology
MH  - HEK293 Cells
MH  - Humans
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Neural Stem Cells/*cytology/drug effects/metabolism/transplantation
MH  - Neurogenesis/drug effects
MH  - Neurons/*cytology/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Stem Cell Transplantation
PMC - PMC3798289
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/10/23 06:00
MHDA- 2014/08/15 06:00
PMCR- 2013/10/17
CRDT- 2013/10/23 06:00
PHST- 2013/05/14 00:00 [received]
PHST- 2013/08/28 00:00 [accepted]
PHST- 2013/10/23 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
PHST- 2013/10/17 00:00 [pmc-release]
AID - PONE-D-13-19862 [pii]
AID - 10.1371/journal.pone.0076860 [doi]
PST - epublish
SO  - PLoS One. 2013 Oct 17;8(10):e76860. doi: 10.1371/journal.pone.0076860. 
      eCollection 2013.