PMID- 24147542
OWN - NLM
STAT- MEDLINE
DCOM- 20140604
LR  - 20221207
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 54
IP  - 4
DP  - 2014 Apr
TI  - The role of alloantibodies against human platelet antigen-15 in multiply platelet 
      transfused patients.
PG  - 1093-9
LID - 10.1111/trf.12455 [doi]
AB  - BACKGROUND: Several studies have documented the role of antibodies against human 
      platelet (PLT) antigen (HPA)-15 in alloimmune-mediated thrombocytopenia including 
      neonatal alloimmune thrombocytopenia, PLT transfusion refractoriness (PTR), and 
      posttransfusion purpura in Caucasian persons. However, the relevance of 
      anti-HPA-15 in PTR among the Japanese population is still unclear. STUDY DESIGN 
      AND METHODS: The sera of 305 multiply PLT transfused (MPT) patients, previously 
      investigated for the presence of human leukocyte antigen (HLA) and HPA antibodies 
      by mixed passive hemagglutination, were reexamined for the presence of HPA-15 
      alloantibodies, using the monoclonal antibody-specific immobilization of PLT 
      antigens (MAIPA) technique. RESULTS: Among the 305 MPT samples, antibodies 
      against HPA-15 alloantigen was detected in seven (2.3%), two (0.66%) being 
      anti-HPA-15a and five (1.64%) being anti-HPA-15b. Additionally, one case of CD109 
      panreactive antibody was found (0.33%). Among them, one aplastic anemia patient 
      with blood group O developed multispecific anti-HLA and anti-HPA-15b alloantibody 
      after MPTs. However, transfusion with HLA-matched PLTs of blood group AB did not 
      result in adequate PLT count increment. Analysis of the possible influence of 
      immune anti-A and anti-B by the MAIPA assay resulted negative, indicating that 
      anti-HPA-15b is responsible for the refractory state in this patient. CONCLUSION: 
      In this study, we found alloimmunization against HPA-15a and -15b in Japanese 
      populations and demonstrated the relevance of these antibodies in a patient with 
      PTR.
CI  - (c) 2013 American Association of Blood Banks.
FAU - Matsuhashi, Mika
AU  - Matsuhashi M
AD  - Department of Transfusion Medicine, The University of Tokyo, Giessen, Germany; 
      Analytical Laboratory Chemistry, Graduate School of Health Care Sciences, Tokyo 
      Medical and Dental University, Tokyo, Japan.
FAU - Tsuno, Nelson H
AU  - Tsuno NH
FAU - Sone, Shinji
AU  - Sone S
FAU - Mishima, Yuko
AU  - Mishima Y
FAU - Nagura, Yutaka
AU  - Nagura Y
FAU - Watanabe-Okochi, Naoko
AU  - Watanabe-Okochi N
FAU - Ikeda, Toshiyuki
AU  - Ikeda T
FAU - Kashiwase, Koichi
AU  - Kashiwase K
FAU - Fukuda, Shinya
AU  - Fukuda S
FAU - Iriyama, Takayuki
AU  - Iriyama T
FAU - Hyodo, Hironobu
AU  - Hyodo H
FAU - Yamashita, Takahiro
AU  - Yamashita T
FAU - Kamei, Yoshimasa
AU  - Kamei Y
FAU - Arai, Shunya
AU  - Arai S
FAU - Minami, Mutsuhiko
AU  - Minami M
FAU - Fujii, Tomoyuku
AU  - Fujii T
FAU - Kurokawa, Mineo
AU  - Kurokawa M
FAU - Tozuka, Minoru
AU  - Tozuka M
FAU - Takahashi, Koki
AU  - Takahashi K
FAU - Santoso, Sentot
AU  - Santoso S
LA  - eng
PT  - Journal Article
DEP - 20131022
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (CD109 protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Isoantibodies)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*immunology
MH  - Antigens, Human Platelet/immunology
MH  - Asian People
MH  - Blood Platelets/*immunology
MH  - Cell Line
MH  - Cohort Studies
MH  - Female
MH  - GPI-Linked Proteins/immunology
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Neoplasm Proteins/*immunology
MH  - *Platelet Transfusion/adverse effects
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/immunology
MH  - Recurrence
MH  - Thrombocytopenia/immunology
EDAT- 2013/10/24 06:00
MHDA- 2014/06/05 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/04/03 00:00 [received]
PHST- 2013/08/05 00:00 [revised]
PHST- 2013/08/07 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/06/05 06:00 [medline]
AID - 10.1111/trf.12455 [doi]
PST - ppublish
SO  - Transfusion. 2014 Apr;54(4):1093-9. doi: 10.1111/trf.12455. Epub 2013 Oct 22.